Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 6/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | LIG1 | P18858 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 2/20 | 0.30 |
| ▸ | FLT3 | P36888 | 1/20 | 0.30 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.30 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.30 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9027947 | 0.76 | KDM4E (0.33) | KDM4EALDH1A1TSHRGAAHPGD | |
| SCHEMBL659348 | 0.75 | ALDH1A1 (0.43) | KDM4EALDH1A1HPGDNPSR1MAPK1 | |
| SCHEMBL2648567 | 0.75 | KDM4E (0.40) | KDM4EALDH1A1PDE4BTSHRGAA | |
| SCHEMBL658931 | 0.72 | MEN1 (0.39) | KDM4EALDH1A1TSHRGAAPTGS1 | |
| SCHEMBL9028451 | 0.70 | SELL (0.39) | KDM4EALDH1A1GAAHPGDNPSR1 | |
| SCHEMBL12375200 | 0.70 | MEN1 (0.42) | KDM4EALDH1A1TSHRGAAPTGS1 | |
| SCHEMBL8161008 | 0.69 | POLB (0.39) | ALDH1A1GAAPTGS1PTGS2HPGD | |
| SCHEMBL7816047 | 0.68 | HPGD (0.51) | ALDH1A1TSHRGAAHPGDHSD17B10 | |
| SCHEMBL8161827 | 0.68 | SMN1; SMN2 (0.45) | KDM4EALDH1A1TSHRGAAHPGD | |
| SCHEMBL9027573 | 0.68 | KDM4E (0.34) | KDM4EALDH1A1PDE4BTSHRGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445827-B1 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO KK (JP) | 1996-09-25 | — | — | EP | disclosed |
| US-5149834-A | Anticholesterol agent and enzyme inhibitors, for curing arteriosclerosis | FUJIREBIO INC. (JP) | 1992-09-22 | — | — | US | disclosed |
| EP-0445827-A2 | 4-Hydroxytetrahydropyran-2-one derivatives useful as cholesterol and lipid reducing agents | FUJIREBIO INC. (JP) | 1991-09-11 | — | — | EP | disclosed |