Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.79 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.79 |
| ▸ | TP53 | P04637 | 2/20 | 0.79 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.79 |
| ▸ | MAPT | P10636 | 2/20 | 0.79 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.79 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.79 |
| ▸ | MEN1 | O00255 | 2/20 | 0.79 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.79 |
| ▸ | MTOR | P42345 | 1/20 | 0.79 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.79 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.79 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.79 |
| ▸ | THPO | P40225 | 1/20 | 0.79 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.79 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.79 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | BLM | P54132 | 2/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8881949 | 1.00 | KDM4E (0.79) | KDM4ECYP2D6TP53ALOX15MAPT | |
| SCHEMBL8883825 | 1.00 | KDM4E (0.79) | KDM4ECYP2D6TP53ALOX15MAPT | |
| Maleic Acid SCHEMBL8668041 | 0.90 | KDM4E (0.83) | KDM4ECYP2D6TP53ALOX15MAPT | |
| Fumaric Acid SCHEMBL9030046 | 0.90 | KDM4E (0.83) | KDM4ECYP2D6TP53ALOX15MAPT | |
| Fumaric Acid SCHEMBL8883754 | 0.90 | KDM4E (0.83) | KDM4ECYP2D6TP53ALOX15MAPT | |
| SCHEMBL150460 | 0.88 | KDM4E (1.00) | KDM4ECYP2D6TP53ALOX15MAPT | |
| SCHEMBL150459 | 0.88 | KDM4E (1.00) | KDM4ECYP2D6TP53ALOX15MAPT | |
| SCHEMBL12083012 | 0.88 | KDM4E (1.00) | KDM4ECYP2D6TP53ALOX15MAPT | |
| SCHEMBL22215232 | 0.88 | KDM4E (1.00) | KDM4ECYP2D6TP53ALOX15MAPT | |
| SCHEMBL2453645 | 0.88 | KDM4E (1.00) | KDM4ECYP2D6TP53ALOX15MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0484573-B1 | 4- and 6-Carbamates related to physostigmine, a process and intermediates for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1996-03-13 | — | — | EP | disclosed |
| EP-0484573-A1 | 4- and 6-Carbamates related to physostigmine, a process and intermediates for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-05-13 | — | — | EP | disclosed |