Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 2/20 | 0.65 |
| ▸ | KMT2A known ✓ | Q03164 | 2/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.83 |
| ▸ | MAPT | P10636 | 3/20 | 0.83 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.83 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.83 |
| ▸ | LMNA | P02545 | 2/20 | 0.83 |
| ▸ | BLM | P54132 | 2/20 | 0.83 |
| ▸ | G6PD | P11413 | 1/20 | 0.83 |
| ▸ | GMNN | O75496 | 1/20 | 0.83 |
| ▸ | THRB | P10828 | 1/20 | 0.83 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.83 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.83 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.65 |
| ▸ | TP53 | P04637 | 2/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.65 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.65 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.65 |
| ▸ | MTOR | P42345 | 1/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Maleic Acid SCHEMBL8668041 | 1.00 | KDM4E (0.83) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA | |
| Fumaric Acid SCHEMBL9030046 | 1.00 | KDM4E (0.83) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA | |
| Fumaric Acid SCHEMBL2262703 | 0.91 | KDM4E (1.00) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA | |
| Fumaric Acid SCHEMBL29360188 | 0.91 | KDM4E (1.00) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL8881949 | 0.90 | KDM4E (0.79) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL9028804 | 0.90 | KDM4E (0.79) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA | |
| SCHEMBL8883825 | 0.90 | KDM4E (0.79) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA | |
| Fumaric Acid SCHEMBL9029647 | 0.85 | KDM4E (0.64) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA | |
| Maleic Acid SCHEMBL8670810 | 0.85 | KDM4E (0.64) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA | |
| Fumaric Acid SCHEMBL9029655 | 0.85 | KDM4E (0.64) | KDM4EMAPTALDH1A1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5591864-A | CHEMICAL INTERMEDIATES FOR COMPOUNDS WHICH ALLEVIATE MEMORY DYSFUNCITONS | HOECHST MARION ROUSSEL, INC. (US) | 1997-01-07 | — | — | US | claimed |
| US-5591864-A | CHEMICAL INTERMEDIATES FOR COMPOUNDS WHICH ALLEVIATE MEMORY DYSFUNCITONS | HOECHST MARION ROUSSEL, INC. (US) | 1997-01-07 | — | — | US | disclosed |
| EP-0484573-B1 | 4- and 6-Carbamates related to physostigmine, a process and intermediates for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1996-03-13 | — | — | EP | disclosed |
| US-5260452-A | 4- and 6-carbamates related to physostigmine and intermediates for the preparation thereof | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1993-11-09 | — | — | US | disclosed |
| EP-0484573-A1 | 4- and 6-Carbamates related to physostigmine, a process and intermediates for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-05-13 | — | — | EP | disclosed |
| US-5081117-A | Treatment of memory dysfunctions such as in Alzheimer's disease | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1992-01-14 | — | — | US | disclosed |