⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11090462 | 0.85 | — | — | |
| SCHEMBL11428398 | 0.81 | EPHX1 (0.30) | — | |
| SCHEMBL15388594 | 0.74 | — | — | |
| SCHEMBL27813128 | 0.69 | GAA (0.30) | — | |
| SCHEMBL902902 | 0.67 | — | — | |
| SCHEMBL23648172 | 0.64 | — | — | |
| SCHEMBL2399001 | 0.62 | — | — | |
| SCHEMBL16913747 | 0.60 | NOS2 (0.34) | — | |
| SCHEMBL29270871 | 0.60 | — | — | |
| SCHEMBL1871785 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3842074-A1 | PROTEIN-DRUG CONJUGATES | Philogen S.p.A. (IT) | 2021-06-30 | — | — | EP | disclosed |
| US-10344079-B2 | Methods of treating a neoplastic disease | PHILOGEN S.P.A. (IT) | 2019-07-09 | — | — | US | disclosed |
| US-20160039920-A1 | Antibody-Drug Conjugates | PHILOCHEM AG (CH) | 2016-02-11 | — | — | US | disclosed |
| US-9198979-B2 | Thiazolidine linker for the conjugation of drugs to antibodies | PHILOGEN S.P.A. (IT) | 2015-12-01 | — | — | US | disclosed |
| US-20130309257-A1 | Thiazolidine Linker for the Conjugation of Drugs to Antibodies | PHILOGEN S.P.A. (IT) | 2013-11-21 | — | — | US | disclosed |
| EP-2621535-A1 | THIAZOLIDINE LINKER FOR THE CONJUGATION OF DRUGS TO ANTIBODIES | Philogen S.p.A. (IT) | 2013-08-07 | — | — | EP | disclosed |
| WO-2012041451-A1 | THIAZOLIDINE LINKER FOR THE CONJUGATION OF DRUGS TO ANTIBODIES | PHILOGEN S.P.A. (IT) | 2012-04-05 | — | — | WO | disclosed |
| US-4456710-A | ALKALI OR ALKALINE EARTH METAL ORGANIC SULFONATES AS ADHESION PROMOTERS; DISCOLORATION INHIBITION; ACETAL RESINS | HOECHST AKTIENGESELLSCHAFT (DE) | 1984-06-26 | — | — | US | disclosed |
| US-4277577-A | IMPROVED IMPACT STRENGTH | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-07-07 | — | — | US | disclosed |