SCHEMBL9029136

SCHEMBL9029136

Cn1ccnc1C1=Cc2cc(OCCCC(C)(C)C(=O)NC3CCCCC3)ccc2OC1CCc1ccccc1

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 1/20 0.35
SSTR4 P31391 4/20 0.34
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34
PDE3B Q13370 1/20 0.33
PDE3A Q14432 1/20 0.33
P2RY12 Q9H244 1/20 0.33
KDM4E B2RXH2 1/20 0.33
LMNA P02545 1/20 0.33
ALOX12 P18054 1/20 0.33
HTT P42858 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
L3MBTL1 Q9Y468 1/20 0.33
BRD4 O60885 1/20 0.32
EPHX2 P34913 1/20 0.32
PPARG P37231 1/20 0.32
MAOB P27338 1/20 0.32
TP53 P04637 1/20 0.32
MAPT P10636 1/20 0.32
EPHX1 P07099 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9029945 0.93 SSTR4 (0.37) SSTR4MEN1KMT2APDE3BPDE3A
SCHEMBL9030891 0.89 PPARA (0.40) ALOX5PPARG
SCHEMBL9029871 0.89 ALOX5 (0.35) ALOX5LMNAPPARG
SCHEMBL9030817 0.89 KDM4E (0.36) ALOX5MEN1KMT2APDE3BPDE3A
SCHEMBL9029933 0.86 ALOX5 (0.36) ALOX5PPARG
SCHEMBL9030826 0.85 ALOX5 (0.35) ALOX5PPARG
SCHEMBL9030164 0.85 ALOX5 (0.34) ALOX5EPHX2PPARG
SCHEMBL9029661 0.85 KDM4E (0.41) ALOX5MEN1KMT2AKDM4EPPARG
SCHEMBL9675775 0.85 ALOX5 (0.35) ALOX5PPARGMAOB
SCHEMBL9029741 0.85 KMT2A (0.38) MEN1KMT2ATDP1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0513285-B1 IMIDAZOL-2-YL DERIVATIVES OF SUBSTITUTED BICYCLIC COMPOUNDS AND PROCESS FOR THEIR PREPARATION PHARMACIA SPA (IT) 1996-01-24 EP claimed
US-5356920-A Anticholesterol, antilipemic agent FARMITALIA CARLO ERBA SRL. (IT) 1994-10-18 US claimed
WO-1992009582-A1 IMIDAZOL-2-YL DERIVATIVES OF SUBSTITUTED BICYCLIC COMPOUNDS AND PROCESS FOR THEIR PREPARATION FARMITALIA CARLO ERBA SRL (IT) 1992-06-11 WO claimed
EP-0513285-B1 IMIDAZOL-2-YL DERIVATIVES OF SUBSTITUTED BICYCLIC COMPOUNDS AND PROCESS FOR THEIR PREPARATION PHARMACIA SPA (IT) 1996-01-24 EP disclosed
US-5356920-A Anticholesterol, antilipemic agent FARMITALIA CARLO ERBA SRL. (IT) 1994-10-18 US disclosed
WO-1992009582-A1 IMIDAZOL-2-YL DERIVATIVES OF SUBSTITUTED BICYCLIC COMPOUNDS AND PROCESS FOR THEIR PREPARATION FARMITALIA CARLO ERBA SRL (IT) 1992-06-11 WO disclosed