SCHEMBL9029883

SCHEMBL9029883

Cc1cncn1CC#CCN1CCCC1=O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
CHRM2 P08172 3/20 0.60
CHRM5 P08912 3/20 0.60
CHRM1 P11229 3/20 0.60
CYP2D6 P10635 2/20 0.51
CHRM3 P20309 2/20 0.51
CYP1A2 P05177 1/20 0.51
CHRM4 P08173 1/20 0.51
CYP2C9 P11712 1/20 0.51
CYP2C19 P33261 1/20 0.51
ALDH1A1 P00352 1/20 0.51
LMNA P02545 1/20 0.51
TSHR P16473 1/20 0.51
ALOX12 P18054 1/20 0.51
NFKB1 P19838 1/20 0.51
APEX1 P27695 1/20 0.51
MAPK1 P28482 1/20 0.51
PMP22 Q01453 1/20 0.51

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Bromide SCHEMBL9029738 0.99 CHRM2 (0.59) CHRM2CHRM5CHRM1CYP2D6CHRM3
SCHEMBL9030311 0.80 CHRM2 (0.44) CHRM2CHRM5CHRM1CHRM3CHRM4
SCHEMBL9029464 0.78 CHRM2 (0.59) CHRM2CHRM5CHRM1CHRM3CHRM4
SCHEMBL9409665 0.78 CHRM2 (0.39) CHRM2CHRM5CHRM1
SCHEMBL9409682 0.78
Bromide SCHEMBL9030363 0.77 CHRM2 (0.57) CHRM2CHRM5CHRM1CHRM3CHRM4
SCHEMBL9030400 0.76 LMNA (0.47) LMNA
SCHEMBL9029818 0.75 CHRM2 (1.00) CHRM2CHRM5CHRM1CYP2D6CHRM3
SCHEMBL9029767 0.75 CHRM2 (0.64) CHRM2CHRM5CHRM1CYP2D6CHRM3
SCHEMBL9029997 0.75 CHRM2 (0.60) CHRM2CHRM5CHRM1CYP2D6CHRM3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0426714-B1 ACETYLENIC IMIDAZOLES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY UPJOHN CO (US) 1996-04-03 EP claimed
EP-0426714-A1 ACETYLENIC IMIDAZOLES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY. UPJOHN CO (US) 1991-05-15 EP claimed
WO-1990001026-A1 ACETYLENIC IMIDAZOLES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY THE UPJOHN COMPANY (US) 1990-02-08 WO claimed
EP-0426714-B1 ACETYLENIC IMIDAZOLES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY UPJOHN CO (US) 1996-04-03 EP disclosed
US-5100909-A Cholinergic antagonists, analgesics, treatment of Alzheimer*s disease THE UPJOHN COMPANY (US) 1992-03-31 US disclosed
EP-0426714-A1 ACETYLENIC IMIDAZOLES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY. UPJOHN CO (US) 1991-05-15 EP disclosed
WO-1990001026-A1 ACETYLENIC IMIDAZOLES HAVING CENTRAL NERVOUS SYSTEM ACTIVITY THE UPJOHN COMPANY (US) 1990-02-08 WO disclosed