Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | CYSLTR1 | Q9Y271 | 10/20 | 0.47 |
| ▸ | CYSLTR2 | Q9NS75 | 5/20 | 0.47 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9031836 | 1.00 | GPBAR1 (0.51) | GPBAR1TSHRHSD17B10CYSLTR1CYSLTR2 | |
| SCHEMBL9828136 | 0.87 | TSHR (0.55) | GPBAR1TSHRHSD17B10CYSLTR1CYSLTR2 | |
| SCHEMBL7007534 | 0.81 | GPBAR1 (0.67) | GPBAR1CYSLTR1 | |
| SCHEMBL28246862 | 0.80 | NPC1 (0.50) | GPBAR1CYSLTR1CYSLTR2MEN1KMT2A | |
| SCHEMBL9030803 | 0.78 | GPBAR1 (0.50) | GPBAR1CYSLTR1CYSLTR2MEN1KMT2A | |
| SCHEMBL9030812 | 0.78 | GPBAR1 (0.50) | GPBAR1CYSLTR1CYSLTR2MEN1KMT2A | |
| SCHEMBL9032817 | 0.77 | GPBAR1 (0.52) | GPBAR1CYSLTR1CYSLTR2MEN1KMT2A | |
| SCHEMBL9032810 | 0.77 | GPBAR1 (0.52) | GPBAR1CYSLTR1CYSLTR2MEN1KMT2A | |
| SCHEMBL9033055 | 0.77 | GPBAR1 (0.85) | GPBAR1CYSLTR1CYSLTR2 | |
| SCHEMBL9033119 | 0.77 | GPBAR1 (0.85) | GPBAR1CYSLTR1CYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0397697-B1 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4? | RHONE POULENC RORER INT (US) | 1996-08-28 | — | — | EP | disclosed |
| US-5166210-A | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D4 | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1992-11-24 | — | — | US | disclosed |
| EP-0397697-A4 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4? | — | 1991-07-03 | — | — | EP | disclosed |
| US-5028615-A | Treatment of hypersensitivity | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-07-02 | — | — | US | disclosed |
| EP-0397697-A1 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4?. | RORER INT OVERSEAS (US) | 1990-11-22 | — | — | EP | disclosed |
| US-4920130-A | ANTIALLERGENS, ANTIINFLAMMATORY AGENTS | RORER PHARAMCEUTICAL CORP. (US) | 1990-04-24 | — | — | US | disclosed |
| WO-1989004304-A1 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D4 | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1989-05-18 | — | — | WO | disclosed |