Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | CYSLTR1 | Q9Y271 | 7/20 | 0.52 |
| ▸ | GPBAR1 | Q8TDU6 | 3/20 | 0.52 |
| ▸ | SLC16A3 | O15427 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.46 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9031829 | 0.87 | GPBAR1 (0.51) | TSHRHSD17B10CYSLTR1GPBAR1SLC16A3 | |
| SCHEMBL9031836 | 0.87 | GPBAR1 (0.51) | TSHRHSD17B10CYSLTR1GPBAR1SLC16A3 | |
| SCHEMBL7007534 | 0.87 | GPBAR1 (0.67) | CYSLTR1GPBAR1FFAR1AKR1B1 | |
| SCHEMBL3271805 | 0.84 | GPBAR1 (0.62) | CYSLTR1GPBAR1FFAR1AKR1B1HDAC1 | |
| SCHEMBL28246862 | 0.81 | NPC1 (0.50) | CYSLTR1GPBAR1CYSLTR2ALDH1A1 | |
| SCHEMBL10422378 | 0.79 | GPBAR1 (0.56) | CYSLTR1GPBAR1FFAR1AKR1B1 | |
| SCHEMBL28330248 | 0.77 | FAAH (0.43) | CYSLTR1CYSLTR2 | |
| SCHEMBL9829523 | 0.77 | GPBAR1 (0.51) | CYSLTR1GPBAR1FFAR1AKR1B1HDAC1 | |
| SCHEMBL9828175 | 0.77 | GPBAR1 (0.53) | CYSLTR1GPBAR1FFAR1AKR1B1HDAC1 | |
| SCHEMBL28330143 | 0.76 | KDM4E (0.54) | HSD17B10ALDH1A1RCE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5051427-A | Antiinflammatory agents and antiallergens | RHONE-POULENC RORER PHARMACEUTICALS INC. (US) | 1991-09-24 | — | — | US | disclosed |
| EP-0395697-A4 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4? | — | 1991-03-13 | — | — | EP | disclosed |
| EP-0395697-A1 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D 4 | RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC. (US) | 1990-11-07 | — | — | EP | disclosed |
| US-4920133-A | Quinoline derivatives and use thereof as antagonists of leukotriene D4 | RORER PHARMACEUTICAL CORP. (US) | 1990-04-24 | — | — | US | disclosed |
| WO-1989004303-A1 | QUINOLINE DERIVATIVES AS ANTAGONISTS OF LEUKOTRIENE D4 | RORER INTERNATIONAL (OVERSEAS) INC. (US) | 1989-05-18 | — | — | WO | disclosed |