SCHEMBL9031978

SCHEMBL9031978

CCNc1nc2c(C)sc(C(=O)O)c2n1Cc1ccc(-c2ccccc2-c2nnn[nH]2)cc1

nearest known ligand 0.55

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 3/20 0.38
AGTR2 P50052 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9031285 0.94 AGTR1 (0.38) AGTR1AGTR2
SCHEMBL9029855 0.93 AGTR1 (0.41) AGTR1AGTR2
SCHEMBL9031719 0.88 PPARG (0.48) AGTR1AGTR2
SCHEMBL9032950 0.88 AGTR1 (0.37) AGTR1AGTR2
SCHEMBL9033635 0.87 AGTR1 (0.40) AGTR1AGTR2
SCHEMBL9031141 0.86 AGTR1 (0.49) AGTR1AGTR2
SCHEMBL9030527 0.86 AGTR1 (0.39) AGTR1AGTR2
SCHEMBL9030640 0.85 AGTR1 (0.42) AGTR1
SCHEMBL7013391 0.85 MAPT (0.37)
SCHEMBL7015939 0.85 MAPT (0.37)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0483683-B1 Thienoimidazole derivatives, their production and use TAKEDA CHEMICAL INDUSTRIES LTD (JP) 1996-02-28 EP disclosed
US-5463073-A Angiotensin II antagonists TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) 1995-10-31 US disclosed
EP-0483683-A2 Thienoimidazole derivatives, their production and use Takeda Chemical Industries, Ltd. (JP) 1992-05-06 EP disclosed