Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 5/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | PI4KA | P42356 | 2/20 | 0.36 |
| ▸ | PI4K2B | Q8TCG2 | 2/20 | 0.36 |
| ▸ | PI4K2A | Q9BTU6 | 2/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.36 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | CNR1 | P21554 | 2/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | NSD2 | O96028 | 2/20 | 0.31 |
| ▸ | NSD3 | Q9BZ95 | 2/20 | 0.31 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL899853 | 0.71 | CYP17A1 (0.69) | CYP17A1CYP1A2 | |
| SCHEMBL16247699 | 0.68 | ADORA1 (0.44) | CYP1A2ADORA2AADORA1PDE4APDE4B | |
| SCHEMBL127827 | 0.68 | PNP (0.36) | NSD2NSD3 | |
| SCHEMBL21085179 | 0.67 | PNP (0.35) | NSD2NSD3 | |
| SCHEMBL18411581 | 0.67 | PNP (0.35) | PI4KAPI4K2BPI4K2API4KBADORA2A | |
| SCHEMBL12775412 | 0.67 | PI4KA (0.51) | CYP17A1CYP1A2PI4KAPI4K2BPI4K2A | |
| SCHEMBL12844273 | 0.67 | PI4KA (0.48) | CYP17A1CYP1A2PI4KAPI4K2BPI4K2A | |
| SCHEMBL30668845 | 0.64 | CYP11B1 (0.37) | CYP17A1CYP1A2ADORA2AADORA1HTR6 | |
| SCHEMBL20637862 | 0.64 | CYP11B1 (0.37) | CYP17A1CYP1A2ADORA2AADORA1HTR6 | |
| SCHEMBL24463107 | 0.62 | CYP17A1 (0.37) | CYP17A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9133160-B2 | Substituted benzimidazole and imidazopyridine compounds useful as CYP17 modulators | BRISTOL-MEYERS SQUIBB COMPANY (US) | 2015-09-15 | — | — | US | disclosed |
| US-9133160-B2 | Substituted benzimidazole and imidazopyridine compounds useful as CYP17 modulators | BRISTOL-MEYERS SQUIBB COMPANY (US) | 2015-09-15 | — | — | US | disclosed |
| US-9133160-B2 | Substituted benzimidazole and imidazopyridine compounds useful as CYP17 modulators | BRISTOL-MEYERS SQUIBB COMPANY (US) | 2015-09-15 | — | — | US | disclosed |
| EP-2621913-B1 | SUBSTITUTED BENZIMIDAZOLE AND IMIDAZOPYRIDINE COMPOUNDS USEFUL AS CYP17 MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2014-11-19 | — | — | EP | disclosed |
| EP-2621913-B1 | SUBSTITUTED BENZIMIDAZOLE AND IMIDAZOPYRIDINE COMPOUNDS USEFUL AS CYP17 MODULATORS | BRISTOL MYERS SQUIBB CO (US) | 2014-11-19 | — | — | EP | disclosed |
| US-20130310393-A1 | SUBSTITUTED BENZIMIDAZOLE AND IMIDAZOPYRIDINE COMPOUNDS USEFUL AS CYP17 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-11-21 | — | — | US | disclosed |
| US-20130310393-A1 | SUBSTITUTED BENZIMIDAZOLE AND IMIDAZOPYRIDINE COMPOUNDS USEFUL AS CYP17 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-11-21 | — | — | US | disclosed |
| WO-2012044537-A1 | SUBSTITUTED BENZIMIDAZOLE AND IMIDAZOPYRIDINE COMPOUNDS USEFUL AS CYP17 MODULATORS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-04-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130310393-A1 | SUBSTITUTED BENZIMIDAZOLE AND IMIDAZOPYRIDINE COMPOUNDS USEFUL AS CYP17 MODULATORS | CYP3A43, CYP2C18, CYP3A7 | CYP17A1 40/4885CYP1A2 12/4885PI4KA 1003/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.