Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.59 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | PLG | P00747 | 1/20 | 0.49 |
| ▸ | PLAU | P00749 | 1/20 | 0.49 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.47 |
| ▸ | PPARG | P37231 | 2/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.46 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9033027 | 1.00 | HDAC8 (0.59) | HDAC8HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL9034330 | 0.89 | HDAC6 (0.60) | HDAC8HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL9034319 | 0.89 | HDAC6 (0.60) | HDAC8HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL9032886 | 0.89 | HDAC8 (0.52) | HDAC8HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL9032866 | 0.89 | HDAC8 (0.52) | HDAC8HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL9034387 | 0.88 | NR4A1 (0.55) | HDAC8HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL9034378 | 0.88 | NR4A1 (0.55) | HDAC8HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL9033502 | 0.87 | HDAC6 (0.67) | HDAC8HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL9033481 | 0.87 | HDAC6 (0.67) | HDAC8HDAC6HDAC3HDAC1HDAC2 | |
| SCHEMBL9031382 | 0.86 | EPHX2 (0.53) | HDAC8HDAC6HDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0511477-B1 | Indole derivatives | KYOWA HAKKO KOGYO KK (JP) | 1996-07-10 | — | — | EP | disclosed |
| US-5239083-A | Anticarcinogenic agents, prostate cancer treatment | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-08-24 | — | — | US | disclosed |
| EP-0511477-A1 | Indole derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-11-04 | — | — | EP | disclosed |