Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.67 |
| ▸ | HDAC8 | Q9BY41 | 9/20 | 0.67 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.67 |
| ▸ | HDAC1 | Q13547 | 8/20 | 0.62 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.62 |
| ▸ | HDAC3 | O15379 | 7/20 | 0.62 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.62 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.56 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.56 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.56 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.56 |
| ▸ | PLG | P00747 | 1/20 | 0.48 |
| ▸ | PLAU | P00749 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9033481 | 1.00 | HDAC6 (0.67) | HDAC6HDAC8HDAC11HDAC1HDAC2 | |
| SCHEMBL9034319 | 0.88 | HDAC6 (0.60) | HDAC6HDAC8HDAC11HDAC1HDAC2 | |
| SCHEMBL9034330 | 0.88 | HDAC6 (0.60) | HDAC6HDAC8HDAC11HDAC1HDAC2 | |
| SCHEMBL9032886 | 0.88 | HDAC8 (0.52) | HDAC6HDAC8HDAC11HDAC1HDAC2 | |
| SCHEMBL9032866 | 0.88 | HDAC8 (0.52) | HDAC6HDAC8HDAC11HDAC1HDAC2 | |
| SCHEMBL9033027 | 0.87 | HDAC8 (0.59) | HDAC6HDAC8HDAC11HDAC1HDAC2 | |
| SCHEMBL9033003 | 0.87 | HDAC8 (0.59) | HDAC6HDAC8HDAC11HDAC1HDAC2 | |
| SCHEMBL28573537 | 0.86 | HDAC6 (0.76) | HDAC6HDAC8HDAC11HDAC1HDAC2 | |
| SCHEMBL9031396 | 0.85 | EPHX2 (0.53) | HDAC6HDAC8HDAC11HDAC1HDAC2 | |
| SCHEMBL9031382 | 0.85 | EPHX2 (0.53) | HDAC6HDAC8HDAC11HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0511477-B1 | Indole derivatives | KYOWA HAKKO KOGYO KK (JP) | 1996-07-10 | — | — | EP | disclosed |
| US-5239083-A | Anticarcinogenic agents, prostate cancer treatment | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-08-24 | — | — | US | disclosed |
| EP-0511477-A1 | Indole derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-11-04 | — | — | EP | disclosed |