Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1B | P28222 | 7/20 | 0.47 |
| ▸ | HTR1D | P28221 | 5/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.43 |
| ▸ | NOS3 | P29474 | 4/20 | 0.42 |
| ▸ | NOS1 | P29475 | 4/20 | 0.42 |
| ▸ | HTR6 | P50406 | 6/20 | 0.41 |
| ▸ | GABRP | O00591 | 1/20 | 0.40 |
| ▸ | GABRD | O14764 | 1/20 | 0.40 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.40 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.40 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.40 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.40 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.40 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.40 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.40 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.40 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.40 |
| ▸ | GABRE | P78334 | 1/20 | 0.40 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.40 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9033149 | 1.00 | HTR1B (0.47) | HTR1BHTR1DHTR1ANOS3NOS1 | |
| SCHEMBL8914053 | 0.90 | HTR1B (0.46) | HTR1BHTR1DHTR1ANOS3NOS1 | |
| SCHEMBL8914049 | 0.90 | HTR1B (0.46) | HTR1BHTR1DHTR1ANOS3NOS1 | |
| SCHEMBL8914526 | 0.90 | HTR1B (0.46) | HTR1BHTR1DHTR1AHTR6GABRP | |
| SCHEMBL8914540 | 0.90 | HTR1B (0.46) | HTR1BHTR1DHTR1AHTR6GABRP | |
| SCHEMBL9034694 | 0.86 | GABRP (0.51) | HTR1BHTR1DHTR1ANOS3NOS1 | |
| SCHEMBL9034686 | 0.86 | GABRP (0.51) | HTR1BHTR1DHTR1ANOS3NOS1 | |
| SCHEMBL8915663 | 0.85 | HTR1B (0.48) | HTR1BHTR1DHTR1ANOS3NOS1 | |
| SCHEMBL8915670 | 0.85 | HTR1B (0.48) | HTR1BHTR1DHTR1ANOS3NOS1 | |
| SCHEMBL8914084 | 0.84 | HTR1B (0.66) | HTR1BHTR1DHTR1ANOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0695301-B1 | INDOLE DERIVATIVES AS 5-HT1-LIKE AGONISTS FOR USE IN MIGRAINE | PFIZER LTD (GB) | 1996-10-30 | — | — | EP | disclosed |