Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.78 |
| ▸ | LMNA | P02545 | 1/20 | 0.78 |
| ▸ | MAPT | P10636 | 1/20 | 0.78 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.78 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.78 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.78 |
| ▸ | ADORA3 | P0DMS8 | 5/20 | 0.72 |
| ▸ | ADORA1 | P30542 | 5/20 | 0.72 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.72 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.72 |
| ▸ | THPO | P40225 | 1/20 | 0.72 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.69 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.65 |
| ▸ | PRKAG1 | P54619 | 1/20 | 0.65 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.65 |
| ▸ | PRKAB1 | Q9Y478 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9033402 | 1.00 | TSHR (0.78) | TSHRLMNAMAPTNPSR1CYP3A4 | |
| SCHEMBL5497088 | 0.92 | SLC29A1 (0.78) | ADORA3ADORA1ADORA2ASLC29A1ADORA2B | |
| SCHEMBL4801562 | 0.92 | SLC29A1 (0.78) | ADORA3ADORA1ADORA2ASLC29A1ADORA2B | |
| SCHEMBL1230660 | 0.88 | TSHR (1.00) | TSHRLMNAMAPTNPSR1CYP3A4 | |
| SCHEMBL29464000 | 0.88 | TSHR (1.00) | TSHRLMNAMAPTNPSR1CYP3A4 | |
| SCHEMBL1230662 | 0.88 | TSHR (1.00) | TSHRLMNAMAPTNPSR1CYP3A4 | |
| SCHEMBL16585344 | 0.88 | TSHR (1.00) | TSHRLMNAMAPTNPSR1CYP3A4 | |
| SCHEMBL14713300 | 0.86 | PRKAG1 (0.83) | TSHRLMNAMAPTNPSR1CYP3A4 | |
| SCHEMBL14714023 | 0.86 | PRKAG1 (0.83) | TSHRLMNAMAPTNPSR1CYP3A4 | |
| SCHEMBL20626253 | 0.86 | PRKAG1 (0.83) | TSHRLMNAMAPTNPSR1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0689405-A4 | METHODS FOR PROTECTING TISSUES AND ORGANS FROM ISCHEMIC DAMAGE | GENSIA INC (US) | 1996-09-11 | — | — | EP | disclosed |
| EP-0689405-A1 | METHODS FOR PROTECTING TISSUES AND ORGANS FROM ISCHEMIC DAMAGE | GENSIA, INC. (US) | 1996-01-03 | — | — | EP | disclosed |
| WO-1994021195-A1 | METHODS FOR PROTECTING TISSUES AND ORGANS FROM ISCHEMIC DAMAGE | GENSIA, INC. (US) | 1994-09-29 | — | — | WO | disclosed |