Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 6/20 | 0.78 |
| ▸ | HDAC8 | Q9BY41 | 6/20 | 0.78 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.78 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.78 |
| ▸ | HDAC3 | O15379 | 4/20 | 0.78 |
| ▸ | HDAC10 | Q969S8 | 4/20 | 0.78 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.78 |
| ▸ | HDAC7 | Q8WUI4 | 3/20 | 0.78 |
| ▸ | HDAC11 | Q96DB2 | 3/20 | 0.78 |
| ▸ | HDAC9 | Q9UKV0 | 3/20 | 0.78 |
| ▸ | HDAC5 | Q9UQL6 | 3/20 | 0.78 |
| ▸ | NPC1 | O15118 | 1/20 | 0.67 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.67 |
| ▸ | PLA2G4A | P47712 | 2/20 | 0.62 |
| ▸ | APP | P05067 | 6/20 | 0.62 |
| ▸ | BACE1 | P56817 | 2/20 | 0.61 |
| ▸ | SNCA | P37840 | 4/20 | 0.60 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7712681 | 1.00 | HDAC1 (0.78) | HDAC1HDAC8HDAC2HDAC6HDAC3 | |
| SCHEMBL8388266 | 0.90 | BACE1 (0.74) | HDAC1HDAC8HDAC2HDAC6HDAC3 | |
| SCHEMBL2510471 | 0.88 | HDAC1 (1.00) | HDAC1HDAC8HDAC2HDAC6HDAC3 | |
| SCHEMBL2510469 | 0.88 | HDAC1 (1.00) | HDAC1HDAC8HDAC2HDAC6HDAC3 | |
| SCHEMBL7712587 | 0.87 | HDAC1 (0.70) | HDAC1HDAC8HDAC2HDAC6HDAC3 | |
| SCHEMBL14207388 | 0.82 | NPC1 (0.67) | HDAC1HDAC8HDAC2HDAC6HDAC3 | |
| SCHEMBL9034832 | 0.81 | HDAC8 (0.56) | HDAC1HDAC8HDAC2HDAC6HDAC3 | |
| SCHEMBL9034823 | 0.80 | APP (0.65) | HDAC1HDAC8HDAC2HDAC6HDAC3 | |
| SCHEMBL9034828 | 0.80 | APP (0.65) | HDAC1HDAC8HDAC2HDAC6HDAC3 | |
| SCHEMBL14207389 | 0.78 | NPC1 (0.62) | HDAC1HDAC8HDAC2HDAC6HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0511477-B1 | Indole derivatives | KYOWA HAKKO KOGYO KK (JP) | 1996-07-10 | — | — | EP | disclosed |
| US-5239083-A | Anticarcinogenic agents, prostate cancer treatment | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-08-24 | — | — | US | disclosed |
| EP-0511477-A1 | Indole derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-11-04 | — | — | EP | disclosed |