Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 6/20 | 0.65 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.61 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.61 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.61 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.61 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.61 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.61 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.61 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.61 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 1/20 | 0.58 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.58 |
| ▸ | SNCA | P37840 | 4/20 | 0.52 |
| ▸ | BACE1 | P56817 | 2/20 | 0.47 |
| ▸ | TBXAS1 | P24557 | 3/20 | 0.46 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.45 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9034823 | 1.00 | APP (0.65) | APPHDAC8HDAC6HDAC3HDAC1 | |
| SCHEMBL9057916 | 0.90 | APP (0.65) | APPHDAC8HDAC6HDAC3HDAC1 | |
| SCHEMBL9057914 | 0.90 | APP (0.65) | APPHDAC8HDAC6HDAC3HDAC1 | |
| SCHEMBL14207388 | 0.80 | NPC1 (0.67) | APPHDAC8HDAC6HDAC3HDAC1 | |
| SCHEMBL9033657 | 0.80 | HDAC1 (0.78) | APPHDAC8HDAC6HDAC3HDAC1 | |
| SCHEMBL7712681 | 0.80 | HDAC1 (0.78) | APPHDAC8HDAC6HDAC3HDAC1 | |
| SCHEMBL9033706 | 0.77 | HDAC8 (0.52) | APPHDAC8HDAC6HDAC3HDAC1 | |
| SCHEMBL9033696 | 0.77 | HDAC8 (0.52) | APPHDAC8HDAC6HDAC3HDAC1 | |
| SCHEMBL9033981 | 0.77 | — | — | |
| SCHEMBL2510469 | 0.76 | HDAC1 (1.00) | APPHDAC8HDAC6HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0511477-B1 | Indole derivatives | KYOWA HAKKO KOGYO KK (JP) | 1996-07-10 | — | — | EP | disclosed |
| US-5239083-A | Anticarcinogenic agents, prostate cancer treatment | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-08-24 | — | — | US | disclosed |
| EP-0511477-A1 | Indole derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-11-04 | — | — | EP | disclosed |