Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.50 |
| ▸ | PLG | P00747 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.47 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.47 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.47 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.47 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.45 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.45 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.45 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.45 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.45 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 1/20 | 0.44 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9033656 | 1.00 | PLAU (0.50) | PLAUPLGHDAC3HDAC1HDAC2 | |
| SCHEMBL9032866 | 0.90 | HDAC8 (0.52) | PLAUPLGHDAC3HDAC1HDAC2 | |
| SCHEMBL9032886 | 0.90 | HDAC8 (0.52) | PLAUPLGHDAC3HDAC1HDAC2 | |
| SCHEMBL9034330 | 0.87 | HDAC6 (0.60) | PLAUPLGHDAC3HDAC1HDAC2 | |
| SCHEMBL9034319 | 0.87 | HDAC6 (0.60) | PLAUPLGHDAC3HDAC1HDAC2 | |
| SCHEMBL30185512 | 0.86 | PLAU (0.56) | PLAUPLGHDAC3HDAC1HDAC2 | |
| SCHEMBL28580033 | 0.86 | PLAU (0.56) | PLAUPLGHDAC3HDAC1HDAC2 | |
| SCHEMBL9033662 | 0.83 | HDAC3 (0.44) | PLAUPLGHDAC3HDAC1HDAC2 | |
| SCHEMBL9033003 | 0.82 | HDAC8 (0.59) | PLAUPLGHDAC3HDAC1HDAC2 | |
| SCHEMBL9033027 | 0.82 | HDAC8 (0.59) | PLAUPLGHDAC3HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0511477-B1 | Indole derivatives | KYOWA HAKKO KOGYO KK (JP) | 1996-07-10 | — | — | EP | disclosed |
| US-5239083-A | Anticarcinogenic agents, prostate cancer treatment | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1993-08-24 | — | — | US | disclosed |
| EP-0511477-A1 | Indole derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1992-11-04 | — | — | EP | disclosed |