Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.49 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.39 |
| ▸ | DPP4 | P27487 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | CA7 | P43166 | 1/20 | 0.39 |
| ▸ | CA9 | Q16790 | 1/20 | 0.39 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | XBP1 | P17861 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9033716 | 1.00 | MAPT (0.49) | MAPTHCAR2ALDH1A1TTRDPP4 | |
| SCHEMBL3668258 | 0.82 | HCAR2 (0.41) | MAPTHCAR2ALDH1A1CA12CA1 | |
| SCHEMBL5652124 | 0.82 | NFE2L2 (0.50) | MAPTHCAR2ALDH1A1TTRCA12 | |
| SCHEMBL5652121 | 0.82 | NFE2L2 (0.50) | MAPTHCAR2ALDH1A1TTRCA12 | |
| SCHEMBL7609837 | 0.80 | HCAR2 (0.52) | MAPTHCAR2ALDH1A1TTRDPP4 | |
| SCHEMBL11805646 | 0.80 | HCAR2 (0.52) | MAPTHCAR2ALDH1A1TTRDPP4 | |
| SCHEMBL30154063 | 0.78 | MAPT (0.55) | MAPTHCAR2ALDH1A1TTRDPP4 | |
| SCHEMBL28320431 | 0.78 | MAPT (0.55) | MAPTHCAR2ALDH1A1TTRDPP4 | |
| SCHEMBL17269805 | 0.77 | MAPT (0.58) | MAPTHCAR2ALDH1A1TTRDPP4 | |
| SCHEMBL21005409 | 0.77 | MAPT (0.49) | MAPTHCAR2ALDH1A1TTRDPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0705835-A1 | Quinoxalic-2,3-diones with an oxa or thiaheterocyclic fused ring | CIBA-GEIGY AG (CH) | 1996-04-10 | — | — | EP | disclosed |