Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.64 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | CXCR3 | P49682 | 6/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9033831 | 1.00 | HDAC8 (0.64) | HDAC8PTPN1KDM4EALDH1A1CYP1A2 | |
| SCHEMBL9033397 | 0.84 | HDAC8 (0.53) | HDAC8PTPN1TDP1 | |
| SCHEMBL9033407 | 0.84 | HDAC8 (0.53) | HDAC8PTPN1TDP1 | |
| SCHEMBL7045160 | 0.84 | NPSR1 (0.61) | HDAC8PTPN1KDM4EALDH1A1CYP1A2 | |
| SCHEMBL6238826 | 0.83 | HDAC8 (0.70) | HDAC8PTPN1TDP1CXCR3 | |
| SCHEMBL22962110 | 0.82 | HDAC8 (0.57) | HDAC8PTPN1 | |
| SCHEMBL11986410 | 0.81 | HDAC8 (0.53) | HDAC8PTPN1TDP1CXCR3 | |
| SCHEMBL14183936 | 0.81 | HDAC8 (0.62) | HDAC8PTPN1CYP3A4 | |
| SCHEMBL4912811 | 0.80 | HDAC8 (0.49) | HDAC8PTPN1TDP1 | |
| SCHEMBL6246275 | 0.79 | KDM4E (0.70) | KDM4EALDH1A1CYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0696593-A2 | Inhibitors of farnesyl protein transferase | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-02-14 | — | — | EP | disclosed |