Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD4 | P21917 | 18/20 | 0.71 |
| ▸ | DRD2 | P14416 | 18/20 | 0.71 |
| ▸ | DRD3 | P35462 | 16/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 1/20 | 0.47 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9034574 | 0.92 | DRD2 (0.79) | DRD4DRD2DRD3OPRM1 | |
| SCHEMBL8786461 | 0.90 | DRD2 (0.87) | DRD4DRD2DRD3OPRM1 | |
| SCHEMBL8786607 | 0.85 | DRD4 (0.86) | DRD4DRD2DRD3 | |
| SCHEMBL8786997 | 0.83 | DRD2 (1.00) | DRD4DRD2DRD3OPRM1 | |
| SCHEMBL22605906 | 0.83 | DRD2 (0.64) | DRD4DRD2DRD3 | |
| SCHEMBL9035212 | 0.81 | DRD2 (0.68) | DRD4DRD2DRD3OPRM1 | |
| SCHEMBL8916449 | 0.80 | DRD4 (0.84) | DRD4DRD2DRD3OPRM1 | |
| SCHEMBL8786357 | 0.77 | DRD4 (1.00) | DRD4DRD2DRD3 | |
| SCHEMBL8786458 | 0.75 | DRD4 (1.00) | DRD4DRD2DRD3OPRM1 | |
| SCHEMBL8915671 | 0.74 | DRD4 (0.80) | DRD4DRD2DRD3OPRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0719264-A1 | IMIDAZOLONE AND OXAZOLONE DERIVATIVES AS DOPAMINE ANTAGONISTS | MERCK SHARP & DOHME LTD. (GB) | 1996-07-03 | — | — | EP | claimed |
| WO-1995007904-A1 | IMIDAZOLONE AND OXAZOLONE DERIVATIVES AS DOPAMINE ANTAGONISTS | MERCK SHARP & DOHME LIMITED (GB) | 1995-03-23 | — | — | WO | claimed |