⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6976367 | 1.00 | — | — | |
| SCHEMBL6976364 | 1.00 | — | — | |
| SCHEMBL9184177 | 0.79 | — | — | |
| SCHEMBL9661583 | 0.79 | — | — | |
| SCHEMBL289406 | 0.75 | CRBN (0.41) | — | |
| SCHEMBL4905898 | 0.74 | CREBBP (1.00) | — | |
| SCHEMBL14258530 | 0.74 | CREBBP (1.00) | — | |
| SCHEMBL4907033 | 0.74 | CREBBP (1.00) | — | |
| SCHEMBL16611889 | 0.74 | — | — | |
| SCHEMBL5768296 | 0.74 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 38 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11001564-B2 | Substituted chromane-8-carboxamide compounds and analogues thereof, and methods using same | ARBUTUS BIOPHARMA CORPORATION (CA) | 2021-05-11 | — | — | US | disclosed |
| US-20190225593-A1 | SUBSTITUTED CHROMANE-8-CARBOXAMIDE COMPOUNDS AND ANALOGUES THEREOF, AND METHODS USING SAME | ARBUTUS BIOPHARMA CORP (CA) | 2019-07-25 | — | — | US | disclosed |
| WO-2018052967-A1 | SUBSTITUTED CHROMANE-8-CARBOXAMIDE COMPOUNDS AND ANALOGUES THEREOF, AND METHODS USING SAME | ARBUTUS BIOPHARMA, INC. (US) | 2018-03-22 | — | — | WO | disclosed |
| EP-2646436-B1 | MONOBACTAMS | PFIZER (US) | 2015-05-27 | — | — | EP | disclosed |
| US-7943605-B2 | Compounds comprising a lactam or a lactam derivative moiety, processes for making them, and their uses | UCB PHARMA S.A. (BE) | 2011-05-17 | — | — | US | disclosed |
| US-7943605-B2 | Compounds comprising a lactam or a lactam derivative moiety, processes for making them, and their uses | UCB PHARMA S.A. (BE) | 2011-05-17 | — | — | US | disclosed |
| US-20090023708-A1 | Compounds Comprising a Lactam or a Lactam Derivative Moiety, Processes for Making Them, and Their Uses | UCB PHARMA, S.A. (BE) | 2009-01-22 | — | — | US | disclosed |
| US-20090023708-A1 | Compounds Comprising a Lactam or a Lactam Derivative Moiety, Processes for Making Them, and Their Uses | UCB PHARMA, S.A. (BE) | 2009-01-22 | — | — | US | disclosed |
| WO-2007048595-A1 | COMPOUNDS COMPRISING A LACTAM OR A LACTAM DERIVATIVE MOIETY, PROCESSES FOR MAKING THEM, AND THEIR USES | UCB PHARMA, S.A. (BE) | 2007-05-03 | — | — | WO | disclosed |
| EP-0362902-B1 | Process and intermediates for beta-lactam antibiotics | HARVARD COLLEGE (US) | 1996-01-17 | — | — | EP | disclosed |
| US-4378315-A | Process for the preparation of thienamycin and intermediates | MERCK & CO., INC. (US) | 1983-03-29 | — | — | US | disclosed |
| EP-0066301-A1 | Intermediates for the preparation of thienamycin and process for preparing the same | MERCK & CO. INC. (US) | 1982-12-08 | — | — | EP | disclosed |
| US-4309346-A | INTERMEDIATES FOR AMINO ACID DERIVATIVE ANTIBIOTICS | MERCK & CO., INC. (US) | 1982-01-05 | — | — | US | disclosed |
| EP-0037082-A1 | Process for the preparation of 1-carbapenems and intermediates via silyl-substituted dithioacetals | MERCK & CO. INC. (US) | 1981-10-07 | — | — | EP | disclosed |
| EP-0037081-A1 | Process for the preparation of 1-carbapenems and intermediates via trithioorthoacetates | MERCK & CO. INC. (US) | 1981-10-07 | — | — | EP | disclosed |
| US-4290947-A | Process for the preparation of thienamycin and intermediates | MERCK & CO., INC. (US) | 1981-09-22 | — | — | US | disclosed |
| US-4275207-A | Process for preparing 7-(1-hydroxyethyl)-3-(2-aminoethylthio)-1-carbadethiaceph-3-em-3-carboxylic acid and intermediate therefor | MERCK & CO., INC. (US) | 1981-06-23 | — | — | US | disclosed |
| EP-0026816-A1 | Intermediates for the preparation of thienamycin and process for preparing intermediates | MERCK & CO. INC. (US) | 1981-04-15 | — | — | EP | disclosed |
| EP-0007973-A1 | Process for the preparation of thienamycin and intermediates | MERCK & CO. INC. (US) | 1980-02-20 | — | — | EP | disclosed |
| US-4174316-A | 4-Iodomethylazetidin-2-one | MERCK & CO., INC. (US) | 1979-11-13 | — | — | US | disclosed |