Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 12/20 | 0.54 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.37 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | GMNN | O75496 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9035394 | 0.91 | TACR1 (0.43) | TACR1SLC6A2SLC6A3HTR2BSLC6A4 | |
| SCHEMBL9055369 | 0.84 | TACR1 (0.63) | TACR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9055364 | 0.84 | TACR1 (0.63) | TACR1TP53CYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9085408 | 0.84 | TACR1 (0.57) | TACR1SLC6A2SLC6A3ADRA1AHTR2B | |
| SCHEMBL9085413 | 0.84 | TACR1 (0.57) | TACR1SLC6A2SLC6A3ADRA1AHTR2B | |
| SCHEMBL8696701 | 0.83 | TACR1 (0.55) | TACR1HTR2BSLC6A4 | |
| SCHEMBL8696694 | 0.83 | TACR1 (0.55) | TACR1HTR2BSLC6A4 | |
| SCHEMBL9034524 | 0.82 | TACR1 (0.49) | TACR1SLC6A2SLC6A3ADRA1AHTR2B | |
| SCHEMBL9034519 | 0.82 | TACR1 (0.49) | TACR1SLC6A2SLC6A3ADRA1AHTR2B | |
| SCHEMBL9036156 | 0.82 | TACR1 (0.49) | TACR1SLC6A2SLC6A3ADRA1AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0734381-A1 | MORPHOLINE AND THIOMORPHOLINE TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO. INC. (US) | 1996-10-02 | — | — | EP | claimed |