Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 12/20 | 0.49 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.36 |
| ▸ | MASP2 | O00187 | 1/20 | 0.35 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.34 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | THPO | P40225 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9036151 | 1.00 | TACR1 (0.49) | TACR1SLC6A2ADRA1AHTR2BSLC6A3 | |
| SCHEMBL9036059 | 0.89 | TACR1 (0.41) | TACR1SLC6A2HTR2BSLC6A3CHRNA7 | |
| SCHEMBL9034524 | 0.87 | TACR1 (0.49) | TACR1SLC6A2ADRA1AHTR2BSLC6A3 | |
| SCHEMBL9034519 | 0.87 | TACR1 (0.49) | TACR1SLC6A2ADRA1AHTR2BSLC6A3 | |
| SCHEMBL8740221 | 0.86 | TACR1 (0.54) | TACR1SLC6A2ADRA1AHTR2BSLC6A3 | |
| SCHEMBL9085413 | 0.82 | TACR1 (0.57) | TACR1SLC6A2ADRA1AHTR2BSLC6A3 | |
| SCHEMBL9085408 | 0.82 | TACR1 (0.57) | TACR1SLC6A2ADRA1AHTR2BSLC6A3 | |
| SCHEMBL9035730 | 0.82 | TACR1 (0.54) | TACR1SLC6A2ADRA1AHTR2BSLC6A3 | |
| SCHEMBL9035343 | 0.81 | TACR1 (0.44) | TACR1SLC6A2SLC6A3 | |
| SCHEMBL9034478 | 0.81 | TACR1 (0.44) | TACR1SLC6A2HTR2BSLC6A3CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0734381-A1 | MORPHOLINE AND THIOMORPHOLINE TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO. INC. (US) | 1996-10-02 | — | — | EP | claimed |