Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 18/20 | 1.00 |
| ▸ | HTR2A | P28223 | 15/20 | 0.73 |
| ▸ | NPC1 | O15118 | 1/20 | 0.72 |
| ▸ | TP53 | P04637 | 1/20 | 0.72 |
| ▸ | PKM | P14618 | 1/20 | 0.72 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.72 |
| ▸ | RAB9A | P51151 | 1/20 | 0.72 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.72 |
| ▸ | RELA | Q04206 | 1/20 | 0.72 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5751582 | 0.86 | HTR2C (0.77) | HTR2CHTR2ANPC1TP53PKM | |
| Hydrochloric Acid SCHEMBL6088350 | 0.85 | HTR2C (0.75) | HTR2CHTR2ANPC1TP53PKM | |
| SCHEMBL6582480 | 0.85 | HTR2C (0.78) | HTR2CHTR2A | |
| SCHEMBL8526803 | 0.85 | HTR2C (1.00) | HTR2CHTR2A | |
| SCHEMBL382910 | 0.84 | NPC1 (1.00) | HTR2CNPC1TP53PKMNFKB1 | |
| SCHEMBL8526274 | 0.84 | HTR2C (0.76) | HTR2CHTR2A | |
| SCHEMBL8529483 | 0.84 | HTR2C (0.76) | HTR2CHTR2A | |
| SCHEMBL8527508 | 0.84 | HTR2C (1.00) | HTR2CHTR2A | |
| SCHEMBL8526818 | 0.84 | HTR2C (1.00) | HTR2CHTR2A | |
| SCHEMBL8529814 | 0.83 | HTR2C (1.00) | HTR2CHTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0707581-A1 | INDOLINE DERIVATIVES AS 5HT 2C? ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-04-24 | — | — | EP | claimed |
| WO-1995001976-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-01-19 | — | — | WO | claimed |
| EP-0707581-A1 | INDOLINE DERIVATIVES AS 5HT 2C? ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1996-04-24 | — | — | EP | disclosed |
| WO-1995001976-A1 | INDOLINE DERIVATIVES AS 5HT2C ANTAGONISTS | SMITHKLINE BEECHAM PLC (GB) | 1995-01-19 | — | — | WO | disclosed |