SCHEMBL903653

SCHEMBL903653

COc1ccc2c(c1)CCC(c1cc(OC)ccc1OC)C2=O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP24A1 Q07973 6/20 0.50
CYP27A1 Q02318 3/20 0.50
CYP26A1 O43174 3/20 0.50
CYP19A1 P11511 1/20 0.50
ALDH1A1 P00352 3/20 0.46
SMN1; SMN2 Q16637 2/20 0.46
GAA P10253 1/20 0.46
HTT P42858 1/20 0.46
MAPT P10636 1/20 0.46
MAPK1 P28482 1/20 0.46
PDE4A P27815 1/20 0.46
PDE4B Q07343 1/20 0.46
PDE4C Q08493 1/20 0.46
PDE4D Q08499 1/20 0.46
KDM4E B2RXH2 1/20 0.45
LMNA P02545 1/20 0.45
DRD2 P14416 1/20 0.45
HTR2A P28223 1/20 0.45
HTR2C P28335 1/20 0.45
HTR2B P41595 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12698728 0.92 CYP24A1 (0.46) CYP24A1CYP27A1CYP26A1CYP19A1ALDH1A1
SCHEMBL903651 0.91 CYP26A1 (0.54) CYP24A1CYP27A1CYP26A1CYP19A1ALDH1A1
SCHEMBL5917029 0.89 CYP24A1 (0.50) CYP24A1CYP27A1CYP26A1CYP19A1ALDH1A1
SCHEMBL5239102 0.82 EGFR (0.45) CYP24A1CYP27A1CYP26A1CYP19A1ALDH1A1
SCHEMBL6669546 0.82 CYP24A1 (0.53) CYP24A1CYP27A1CYP26A1CYP19A1DRD2
SCHEMBL22628601 0.82 CYP24A1 (0.62) CYP24A1CYP27A1CYP26A1CYP19A1ALDH1A1
SCHEMBL31053075 0.82 CYP24A1 (0.62) CYP24A1CYP27A1CYP26A1CYP19A1ALDH1A1
SCHEMBL15804657 0.81 CYP24A1 (0.47) CYP24A1CYP27A1CYP26A1CYP19A1ALDH1A1
SCHEMBL15874767 0.80 CYP24A1 (0.60) CYP24A1CYP27A1CYP26A1CYP19A1ALDH1A1
SCHEMBL4366122 0.80 CYP24A1 (0.60) CYP24A1CYP27A1CYP26A1CYP19A1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012040924-A1 FUSED TETRACYCLIC HETEROCYCLE COMPOUNDS AND METHODS OF USE THEREOF FOR TREATMENT OF VIRAL DISEASES MERCK SHARP & DOHME CORP. (US) 2012-04-05 WO disclosed
WO-2012041227-A1 TETRACYCLIC HETEROCYCLE COMPOUNDS FOR TREATING HEPATITIS C VIRAL INFECTION MERCK SHARP & DOHME CORP. (US) 2012-04-05 WO disclosed