Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.46 |
| ▸ | TTR | P02766 | 1/20 | 0.46 |
| ▸ | PPOX | P50336 | 1/20 | 0.46 |
| ▸ | MERTK | Q12866 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 4/20 | 0.37 |
| ▸ | PIN1 | Q13526 | 3/20 | 0.36 |
| ▸ | PARP1 | P09874 | 1/20 | 0.35 |
| ▸ | ATM | Q13315 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10472248 | 0.92 | TDP1 (0.46) | MEN1KMT2ATDP1TTRPPOX | |
| SCHEMBL10474407 | 0.89 | TDP1 (0.42) | MEN1KMT2ATDP1TTRPPOX | |
| SCHEMBL10474298 | 0.89 | TDP1 (0.42) | MEN1KMT2ATDP1TTRPPOX | |
| SCHEMBL10474409 | 0.89 | TDP1 (0.42) | MEN1KMT2ATDP1TTRPPOX | |
| SCHEMBL10474161 | 0.87 | TDP1 (0.45) | MEN1KMT2ATDP1TTRPPOX | |
| SCHEMBL9474036 | 0.87 | ALDH1A1 (0.45) | MEN1KMT2ATDP1TTRPPOX | |
| SCHEMBL10472059 | 0.86 | TDP1 (0.42) | MEN1KMT2ATDP1TTRPPOX | |
| SCHEMBL10473203 | 0.86 | KMT2A (0.42) | MEN1KMT2ATDP1TTRPPOX | |
| SCHEMBL10474865 | 0.86 | TDP1 (0.43) | MEN1KMT2ATDP1TTRPPOX | |
| SCHEMBL10471868 | 0.86 | TDP1 (0.41) | MEN1KMT2ATDP1TTRPPOX |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0442655-B1 | Benzisoxazole derivatives | ZENECA LTD (GB) | 1996-01-17 | — | — | EP | disclosed |
| US-5185025-A | SUBSTITUTED PYRAZOLES AND THEIR USE AS HERBICIDES | MONSANTO COMPANY (US) | 1993-02-09 | — | — | US | disclosed |
| EP-0371947-A1 | Substituted pyrazoles and their use as herbicides | Monsanto Company (US) | 1990-06-06 | — | — | EP | disclosed |