Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | ACLY | P53396 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL903682 | 0.81 | ACLY (0.34) | PIK3CAPIK3CBPIK3CGACLY | |
| SCHEMBL903685 | 0.81 | ACLY (0.34) | PIK3CAPIK3CBPIK3CGACLY | |
| SCHEMBL17429553 | 0.81 | ACLY (0.34) | PIK3CAPIK3CBPIK3CGACLY | |
| SCHEMBL903693 | 0.80 | EGFR (0.32) | — | |
| SCHEMBL19318923 | 0.79 | PIK3CA (0.31) | PIK3CAPIK3CBPIK3CGTP53MDM2 | |
| SCHEMBL15889362 | 0.76 | — | — | |
| SCHEMBL903506 | 0.75 | MCL1 (0.33) | — | |
| SCHEMBL15898092 | 0.74 | ACLY (0.32) | PIK3CAPIK3CBPIK3CGACLY | |
| SCHEMBL903802 | 0.73 | ACLY (0.39) | ACLY | |
| SCHEMBL17429555 | 0.71 | CYP19A1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041014-A1 | TETRACYCLIC INDOLE DERIVATIVES FOR TREATING HEPATITIS C VIRUS INFECTION | MERCK SHARP & DOHME CORP. (US) | 2012-04-05 | — | — | WO | disclosed |