Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 9/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.48 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | TYMS | P04818 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9038155 | 0.95 | DHFR (0.60) | DHFRKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9037077 | 0.92 | DHFR (0.57) | DHFRKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL8997189 | 0.86 | DHFR (0.58) | DHFRTYMS | |
| SCHEMBL8997192 | 0.86 | DHFR (0.58) | DHFRTYMS | |
| SCHEMBL9037088 | 0.86 | DHFR (0.66) | DHFR | |
| SCHEMBL9343679 | 0.85 | DHFR (0.54) | DHFRKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9037720 | 0.85 | DHFR (0.54) | DHFRKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9343678 | 0.85 | DHFR (0.54) | DHFRKDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9086338 | 0.84 | DHFR (0.58) | DHFRTYMS | |
| SCHEMBL9086345 | 0.84 | DHFR (0.58) | DHFRTYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0722440-A1 | PYRIMIDINYL-GLUTAMIC ACID DERIVATIVES | ELI LILLY AND COMPANY (US) | 1996-07-24 | — | — | EP | disclosed |
| EP-0722440-A4 | PYRIMIDINYL-GLUTAMIC ACID DERIVATIVES | LILLY CO ELI (US) | 1996-06-04 | — | — | EP | disclosed |
| US-5426110-A | Inhibiting dihydrofolate reductase in mammals and treating susceptible reoplasms | ELI LILLY AND COMPANY (US) | 1995-06-20 | — | — | US | disclosed |
| WO-1995009845-A1 | PYRIMIDINYL-GLUTAMIC ACID DERIVATIVES | ELI LILLY AND COMPANY (US) | 1995-04-13 | — | — | WO | disclosed |