Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 6/20 | 0.42 |
| ▸ | MAPT | P10636 | 6/20 | 0.37 |
| ▸ | MEN1 | O00255 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | TP53 | P04637 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 4/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.36 |
| ▸ | CYP1A1 | P04798 | 3/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.36 |
| ▸ | CYP1B1 | Q16678 | 3/20 | 0.36 |
| ▸ | FTO | Q9C0B1 | 3/20 | 0.36 |
| ▸ | CDK1 | P06493 | 3/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6959106 | 0.84 | SMN1; SMN2 (0.47) | SMN1; SMN2L3MBTL1POLBABCB1MAPT | |
| SCHEMBL7367971 | 0.79 | SMN1; SMN2 (0.44) | SMN1; SMN2L3MBTL1POLBABCB1MAPT | |
| SCHEMBL6955608 | 0.75 | SMN1; SMN2 (0.50) | SMN1; SMN2L3MBTL1POLBABCB1MAPT | |
| SCHEMBL7372932 | 0.74 | SMN1; SMN2 (0.52) | SMN1; SMN2L3MBTL1POLBABCB1MAPT | |
| SCHEMBL7377223 | 0.74 | ABCB1 (0.40) | SMN1; SMN2L3MBTL1POLBABCB1MAPT | |
| SCHEMBL7367968 | 0.74 | SMN1; SMN2 (0.44) | SMN1; SMN2L3MBTL1POLBABCB1MAPT | |
| SCHEMBL6955768 | 0.74 | SMN1; SMN2 (0.44) | SMN1; SMN2L3MBTL1POLBABCB1MAPT | |
| SCHEMBL8538762 | 0.73 | SMN1; SMN2 (0.48) | SMN1; SMN2L3MBTL1POLBABCB1MAPT | |
| SCHEMBL6176076 | 0.72 | SMN1; SMN2 (0.50) | SMN1; SMN2L3MBTL1POLBABCB1MAPT | |
| SCHEMBL6954004 | 0.71 | SMN1; SMN2 (0.41) | SMN1; SMN2L3MBTL1POLBABCB1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0729466-A1 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1996-09-04 | — | — | EP | disclosed |
| WO-1995014014-A2 | PYRONE DERIVATIVES AS PROTEASE INHIBITORS AND ANTIVIRAL AGENTS | PARKE, DAVIS & COMPANY (US) | 1995-05-26 | — | — | WO | disclosed |