Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.41 |
| ▸ | RAB9A | P51151 | 8/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.41 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.41 |
| ▸ | RELA | Q04206 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | CASP2 | P42575 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL6968763 | 0.99 | NPC1 (0.41) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| Hydrochloric Acid SCHEMBL9212801 | 0.99 | NPC1 (0.41) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| SCHEMBL27359221 | 0.87 | HTT (0.42) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| SCHEMBL6963665 | 0.87 | HTT (0.42) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| SCHEMBL9037368 | 0.87 | HTT (0.42) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| SCHEMBL9037900 | 0.86 | SMN1; SMN2 (0.41) | NPC1RAB9ASMN1; SMN2MAPTKMT2A | |
| Hydrochloric Acid SCHEMBL8597752 | 0.86 | HTT (0.44) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| Hydrochloric Acid SCHEMBL6969614 | 0.86 | HTT (0.44) | NPC1RAB9ASMN1; SMN2MAPTTP53 | |
| Bromide SCHEMBL6958190 | 0.85 | SMN1; SMN2 (0.40) | NPC1RAB9ASMN1; SMN2MAPTKMT2A | |
| SCHEMBL6966852 | 0.85 | NPC1 (0.44) | NPC1RAB9ASMN1; SMN2MAPTTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0713483-A1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | Astra Aktiebolag (SE) | 1996-05-29 | — | — | EP | claimed |
| WO-1995005363-A1 | AMIDINE DERIVATIVES WITH NITRIC OXIDE SYNTHETASE ACTIVITIES | ASTRA AKTIEBOLAG (SE) | 1995-02-23 | — | — | WO | claimed |