Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.47 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.46 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL903893 | 0.83 | ALDH1A1 (0.54) | KDM4EALDH1A1LMNASMN1; SMN2RECQL | |
| SCHEMBL904002 | 0.83 | KDM4E (0.51) | KDM4EALDH1A1LMNASMN1; SMN2RECQL | |
| SCHEMBL1005879 | 0.82 | KDM4E (0.62) | KDM4EALDH1A1LMNASMN1; SMN2RECQL | |
| SCHEMBL15218460 | 0.81 | ALDH1A1 (0.59) | KDM4EALDH1A1LMNASMN1; SMN2RECQL | |
| SCHEMBL17010819 | 0.80 | KDM4E (0.49) | KDM4EALDH1A1SMN1; SMN2RECQL | |
| SCHEMBL19049372 | 0.79 | HRH3 (0.66) | ALDH1A1SMN1; SMN2GAASIGMAR1HSP90AA1 | |
| SCHEMBL13216206 | 0.78 | ALDH1A1 (0.48) | KDM4EALDH1A1SMN1; SMN2RECQL | |
| SCHEMBL2184353 | 0.77 | ALDH1A1 (0.61) | KDM4EALDH1A1LMNA | |
| SCHEMBL4151517 | 0.77 | SMN1; SMN2 (0.72) | KDM4EALDH1A1LMNASMN1; SMN2SIGMAR1 | |
| SCHEMBL19222086 | 0.77 | ALDH1A1 (0.47) | KDM4EALDH1A1SMN1; SMN2RECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102432598-A | Tricyclic compound, preparation method thereof and pharmaceutical application thereof | JIANGSU HENGRUI MEDICINE CO | 2012-05-02 | — | — | CN | disclosed |
| WO-2012041158-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-04-05 | — | — | WO | disclosed |