Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | TOP2A | P11388 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 4/20 | 0.42 |
| ▸ | MAOB | P27338 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9039530 | 0.94 | MAPK14 (0.47) | MAPK14TOP2AATMHTTKDM4E | |
| SCHEMBL15562548 | 0.90 | MAPK14 (0.49) | MAPK14TOP2AKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL12223747 | 0.87 | TOP2A (0.55) | TOP2AATMHTTKDM4EALDH1A1 | |
| SCHEMBL11188527 | 0.83 | ATM (0.56) | ATMHTTKDM4EALDH1A1GLA | |
| SCHEMBL18381778 | 0.76 | GPR3 (0.61) | TOP2AHTTKDM4EALDH1A1HPGD | |
| SCHEMBL18381818 | 0.76 | GPR3 (0.61) | TOP2AHTTKDM4EALDH1A1HPGD | |
| SCHEMBL29466066 | 0.75 | GPR3 (0.71) | ATMHTTKDM4EALDH1A1GLA | |
| SCHEMBL53107 | 0.75 | GPR3 (0.71) | ATMHTTKDM4EALDH1A1GLA | |
| SCHEMBL30929605 | 0.74 | GPR3 (0.64) | TOP2AHTTKDM4EALDH1A1HPGD | |
| SCHEMBL280032 | 0.74 | GPR3 (0.64) | TOP2AHTTKDM4EALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0347831-B1 | Pyridine derivatives and intermediates thereof | KYOWA HAKKO KOGYO KK (JP) | 1996-12-11 | — | — | EP | disclosed |
| EP-0347831-A2 | Pyridine derivatives and intermediates thereof | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1989-12-27 | — | — | EP | disclosed |