SCHEMBL903909

SCHEMBL903909

CCc1cnc(N2CC3[C@@H](COc4c(F)cc(-c5cncnc5)cc4F)[C@]3(C)C2)nc1

nearest known ligand 0.33

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
GPR119 Q8TDV5 6/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10067568 0.85 GPR119 (0.38) GPR119
SCHEMBL903941 0.80 GPR119 (0.35) GPR119
SCHEMBL1937881 0.78 GPR119 (0.49) GPR119
SCHEMBL904109 0.71 GPR119 (0.45) GPR119
SCHEMBL10067567 0.69 GPR119 (0.42) GPR119
SCHEMBL1937189 0.69 GPR119 (0.49) GPR119
SCHEMBL903988 0.69 GPR119 (0.42) GPR119
SCHEMBL15196540 0.68 GPR119 (0.49) GPR119
SCHEMBL904095 0.68 GPR119 (0.48) GPR119
SCHEMBL1937615 0.67 GPR119 (0.50) GPR119

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2012041158-A1 TRICYCLIC COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF 上海恒瑞医药有限公司 (CN) 2012-04-05 WO disclosed