Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 19/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL903889 | 0.88 | GPR119 (0.47) | GPR119PTGS2 | |
| SCHEMBL903870 | 0.85 | GPR119 (0.46) | GPR119PTGS2CYP3A4KCNH2 | |
| SCHEMBL1937859 | 0.85 | GPR119 (0.56) | GPR119 | |
| SCHEMBL904095 | 0.81 | GPR119 (0.48) | GPR119 | |
| SCHEMBL903891 | 0.80 | GPR119 (0.47) | GPR119PTGS2 | |
| SCHEMBL904082 | 0.80 | GPR119 (0.47) | GPR119PTGS2 | |
| SCHEMBL12017228 | 0.78 | GPR119 (0.42) | GPR119PTGS1PTGS2 | |
| SCHEMBL12017219 | 0.78 | GPR119 (0.42) | GPR119PTGS1PTGS2 | |
| SCHEMBL1935900 | 0.78 | GPR119 (0.55) | GPR119 | |
| SCHEMBL1937855 | 0.76 | GPR119 (0.49) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041158-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-04-05 | — | — | WO | disclosed |