Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | RAB9A | P51151 | 3/20 | 0.50 |
| ▸ | RECQL | P46063 | 1/20 | 0.47 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | F10 | P00742 | 2/20 | 0.45 |
| ▸ | TNF | P01375 | 2/20 | 0.43 |
| ▸ | F2 | P00734 | 1/20 | 0.43 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | PDE2A | O00408 | 2/20 | 0.43 |
| ▸ | CA12 | O43570 | 1/20 | 0.43 |
| ▸ | CA1 | P00915 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.43 |
| ▸ | CA7 | P43166 | 1/20 | 0.43 |
| ▸ | CA9 | Q16790 | 1/20 | 0.43 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9038215 | 0.90 | HPGD (0.53) | NPC1RAB9ARECQLMAPK10SMN1; SMN2 | |
| SCHEMBL25998805 | 0.89 | SIRT2 (0.49) | NPC1RAB9ARECQLMAPK10SMN1; SMN2 | |
| SCHEMBL29738011 | 0.85 | MEN1 (0.54) | NPC1RAB9ARECQLMAPK10SMN1; SMN2 | |
| SCHEMBL6799725 | 0.84 | NPC1 (0.49) | NPC1RAB9ARECQLMAPK10SMN1; SMN2 | |
| SCHEMBL17103068 | 0.84 | BRD4 (0.48) | RAB9ASMN1; SMN2LMNAALDH1A1HPGD | |
| SCHEMBL4916141 | 0.83 | NPC1 (0.48) | NPC1RAB9ARECQLMAPK10SMN1; SMN2 | |
| SCHEMBL3353218 | 0.82 | KCNH2 (0.49) | NPC1RAB9AF10ALDH1A1HPGD | |
| SCHEMBL1608602 | 0.82 | SMN1; SMN2 (0.60) | NPC1RAB9ARECQLMAPK10SMN1; SMN2 | |
| SCHEMBL24075008 | 0.82 | HPGD (0.49) | NPC1RAB9ARECQLMAPK10SMN1; SMN2 | |
| SCHEMBL25999218 | 0.81 | SMN1; SMN2 (0.45) | NPC1RAB9ARECQLMAPK10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0393574-B1 | Hexitol derivatives | KYOWA HAKKO KOGYO KK (JP) | 1996-01-31 | — | — | EP | disclosed |
| US-5053408-A | Cardiovascular disorders | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-10-01 | — | — | US | disclosed |
| EP-0393574-A2 | Hexitol derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1990-10-24 | — | — | EP | disclosed |