Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | DHFR | P00374 | 3/20 | 0.39 |
| ▸ | PPID | Q08752 | 1/20 | 0.38 |
| ▸ | NOD2 | Q9HC29 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PARP1 | P09874 | 1/20 | 0.36 |
| ▸ | CCKBR | P32239 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9052574 | 0.88 | L3MBTL1 (0.57) | L3MBTL1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL1604521 | 0.88 | L3MBTL1 (0.57) | L3MBTL1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL28301445 | 0.83 | L3MBTL1 (0.51) | L3MBTL1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL28301446 | 0.83 | L3MBTL1 (0.51) | L3MBTL1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL27319312 | 0.79 | L3MBTL1 (0.55) | L3MBTL1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL6655031 | 0.79 | L3MBTL1 (0.55) | L3MBTL1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL8321601 | 0.79 | L3MBTL1 (0.55) | L3MBTL1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL1143549 | 0.79 | L3MBTL1 (0.59) | L3MBTL1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL8320541 | 0.79 | L3MBTL1 (0.59) | L3MBTL1KMT2APOLBKDM4EALDH1A1 | |
| SCHEMBL9601970 | 0.79 | L3MBTL1 (0.59) | L3MBTL1KMT2APOLBKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0722440-A1 | PYRIMIDINYL-GLUTAMIC ACID DERIVATIVES | ELI LILLY AND COMPANY (US) | 1996-07-24 | — | — | EP | disclosed |
| EP-0722440-A4 | PYRIMIDINYL-GLUTAMIC ACID DERIVATIVES | LILLY CO ELI (US) | 1996-06-04 | — | — | EP | disclosed |
| US-5426110-A | Inhibiting dihydrofolate reductase in mammals and treating susceptible reoplasms | ELI LILLY AND COMPANY (US) | 1995-06-20 | — | — | US | disclosed |
| WO-1995009845-A1 | PYRIMIDINYL-GLUTAMIC ACID DERIVATIVES | ELI LILLY AND COMPANY (US) | 1995-04-13 | — | — | WO | disclosed |