Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 20/20 | 0.44 |
| ▸ | GPR183 | P32249 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10067421 | 1.00 | GPR119 (0.44) | GPR119GPR183KCNH2CYP3A4CYP2C19 | |
| SCHEMBL388551 | 0.81 | GPR119 (0.59) | GPR119GPR183KCNH2CYP3A4CYP2C19 | |
| SCHEMBL12064711 | 0.78 | GPR119 (0.54) | GPR119GPR183KCNH2CYP3A4CYP2C19 | |
| SCHEMBL904156 | 0.78 | GPR119 (0.62) | GPR119GPR183KCNH2CYP3A4CYP2C19 | |
| SCHEMBL903907 | 0.75 | GPR119 (0.65) | GPR119GPR183KCNH2CYP3A4CYP2C19 | |
| SCHEMBL10067424 | 0.75 | GPR119 (0.54) | GPR119GPR183KCNH2CYP3A4CYP2C19 | |
| SCHEMBL121348 | 0.74 | GPR119 (0.52) | GPR119GPR183KCNH2CYP3A4CYP2C19 | |
| SCHEMBL10067782 | 0.74 | GPR119 (0.68) | GPR119GPR183KCNH2CYP3A4CYP2C19 | |
| SCHEMBL10067576 | 0.74 | GPR119 (0.59) | GPR119GPR183KCNH2CYP3A4CYP2C19 | |
| SCHEMBL904055 | 0.74 | GPR119 (0.68) | GPR119GPR183KCNH2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041158-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-04-05 | — | — | WO | disclosed |