Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 19/20 | 0.51 |
| ▸ | GPR183 | P32249 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL903991 | 0.89 | GPR119 (0.52) | GPR119BRD4 | |
| SCHEMBL388632 | 0.85 | GPR119 (0.69) | GPR119GPR183 | |
| SCHEMBL10067768 | 0.83 | GPR119 (0.47) | GPR119GPR183BRD4 | |
| SCHEMBL904051 | 0.82 | GPR119 (0.51) | GPR119GPR183 | |
| SCHEMBL10067583 | 0.81 | GPR119 (0.59) | GPR119 | |
| SCHEMBL10067575 | 0.79 | GPR119 (0.47) | GPR119GPR183 | |
| SCHEMBL384428 | 0.79 | GPR119 (0.64) | GPR119GPR183 | |
| SCHEMBL387399 | 0.79 | GPR119 (0.60) | GPR119 | |
| SCHEMBL903874 | 0.79 | GPR119 (0.45) | GPR119GPR183 | |
| SCHEMBL388696 | 0.79 | GPR119 (0.60) | GPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041158-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-04-05 | — | — | WO | disclosed |