Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.45 |
| ▸ | GPR119 | Q8TDV5 | 6/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.38 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.38 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.38 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.38 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.38 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.38 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 6/20 | 0.35 |
| ▸ | KIT | P10721 | 2/20 | 0.35 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10068064 | 0.89 | CYP11B1 (0.43) | GPR119NSD2EGLN2 | |
| SCHEMBL903901 | 0.87 | HDAC3 (0.41) | HRH3GPR119HDAC3HDAC4HDAC1 | |
| SCHEMBL904023 | 0.85 | GPR119 (0.41) | GPR119 | |
| SCHEMBL903891 | 0.85 | GPR119 (0.47) | GPR119 | |
| SCHEMBL904082 | 0.85 | GPR119 (0.47) | GPR119 | |
| SCHEMBL1936232 | 0.84 | GPR119 (0.51) | HRH3GPR119KDM1AKIT | |
| SCHEMBL903943 | 0.84 | GPR119 (0.39) | GPR119HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL903941 | 0.84 | GPR119 (0.35) | GPR119 | |
| SCHEMBL903919 | 0.83 | GPR119 (0.42) | HRH3GPR119KDM1AKIT | |
| SCHEMBL903940 | 0.81 | GPR119 (0.36) | GPR119HDAC3HDAC4HDAC1HDAC7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041158-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-04-05 | — | — | WO | disclosed |