Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 14/20 | 0.42 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
| ▸ | LIPE | Q05469 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8511074 | 0.80 | GPR119 (0.47) | GPR119USP30LIPE | |
| SCHEMBL904099 | 0.73 | GPR119 (0.54) | GPR119 | |
| SCHEMBL10106274 | 0.68 | GPR119 (0.55) | GPR119 | |
| SCHEMBL10106468 | 0.68 | GPR119 (0.61) | GPR119 | |
| SCHEMBL16307882 | 0.68 | GPR119 (0.55) | GPR119 | |
| SCHEMBL2887691 | 0.67 | GPR119 (0.55) | GPR119USP30HTTPIK3CA | |
| SCHEMBL10106451 | 0.67 | GPR119 (0.52) | GPR119 | |
| SCHEMBL12170583 | 0.67 | GPR119 (0.54) | GPR119 | |
| SCHEMBL30915773 | 0.67 | NR1H2 (0.60) | GPR119LIPE | |
| SCHEMBL29215623 | 0.67 | NR1H2 (0.60) | GPR119LIPE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041158-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-04-05 | — | — | WO | disclosed |