Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.84 |
| ▸ | SLC18A3 | Q16572 | 3/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23043270 | 0.93 | TDP1 (0.80) | TDP1SLC18A3CHRM4CHRM5CHRM1 | |
| SCHEMBL1856334 | 0.93 | TDP1 (0.80) | TDP1SLC18A3CHRM4CHRM5CHRM1 | |
| SCHEMBL9540610 | 0.93 | TDP1 (0.80) | TDP1SLC18A3CHRM4CHRM5CHRM1 | |
| SCHEMBL19317460 | 0.93 | TDP1 (0.80) | TDP1SLC18A3CHRM4CHRM5CHRM1 | |
| SCHEMBL29366521 | 0.93 | TDP1 (0.80) | TDP1SLC18A3CHRM4CHRM5CHRM1 | |
| Lupinine SCHEMBL914675 | 0.91 | TDP1 (1.00) | TDP1 | |
| Lupinine SCHEMBL177708 | 0.91 | TDP1 (1.00) | TDP1 | |
| Lupinine SCHEMBL2633852 | 0.91 | TDP1 (1.00) | TDP1 | |
| Lupinine SCHEMBL13593464 | 0.91 | TDP1 (1.00) | TDP1 | |
| SCHEMBL1871639 | 0.91 | TDP1 (0.92) | TDP1SLC18A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4205074-A | Anti-spasmodic substituted quinolizidine and indolizidine compounds | HOKURIKU PHARMACEUTICAL CO., LTD. (JP) | 1980-05-27 | — | — | US | claimed |
| JP-55047681-A | — | — | None | — | — | JP | disclosed |
| EP-0449294-B1 | Hydroxymethyl-indolizidines and quinolizidines | MERRELL PHARMA INC (US) | 1996-07-10 | — | — | EP | disclosed |
| EP-0449294-A1 | Hydroxymethyl-indolizidines and quinolizidines | MERRELL PHARMACEUTICALS INC. (US) | 1991-10-02 | — | — | EP | disclosed |
| US-5028614-A | Hydroxymethyl-indolizidines and quinolizidines and their use as α-glucosidase I inhibitors | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-07-02 | — | — | US | disclosed |
| US-4205074-A | Anti-spasmodic substituted quinolizidine and indolizidine compounds | HOKURIKU PHARMACEUTICAL CO., LTD. (JP) | 1980-05-27 | — | — | US | disclosed |
| JP-S5547681-A | INDOLIZIDINE-METHANOL DERIVATIVE AND ITS PREPARATION | HOKURIKU SEIYAKU CO LTD | 1980-04-04 | — | — | JP | disclosed |
| EP-0004260-A1 | Substituted quinolizidine and indolizidine-methanol derivatives, method for their preparation and medicaments containing them | Hokuriku Pharmaceutical Co.,Ltd (JP) | 1979-10-03 | — | — | EP | disclosed |