Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.61 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.61 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.50 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.50 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 1/20 | 0.45 |
| ▸ | QPCT | Q16769 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19611398 | 0.93 | MTNR1A (0.62) | MTNR1AMTNR1BHTTHPGDALDH1A1 | |
| SCHEMBL19911358 | 0.88 | MTNR1A (0.61) | MTNR1AMTNR1BHTTHPGDALDH1A1 | |
| SCHEMBL9041325 | 0.88 | MAPT (0.51) | MTNR1AMTNR1BHTTALDH1A1SMN1; SMN2 | |
| SCHEMBL19911346 | 0.85 | MTNR1A (0.64) | MTNR1AMTNR1BHTTHPGDALDH1A1 | |
| SCHEMBL16406499 | 0.85 | MTNR1A (0.60) | MTNR1AMTNR1BHTTHPGDALDH1A1 | |
| SCHEMBL12479984 | 0.84 | MTNR1A (0.62) | MTNR1AMTNR1BHTTHPGDALDH1A1 | |
| SCHEMBL12479232 | 0.84 | MTNR1A (0.66) | MTNR1AMTNR1BHTTHPGDALDH1A1 | |
| SCHEMBL9120412 | 0.84 | MTNR1A (0.62) | MTNR1AMTNR1BHTTHPGDALDH1A1 | |
| SCHEMBL27038883 | 0.82 | MTNR1A (0.65) | MTNR1AMTNR1BHTTHPGDALDH1A1 | |
| SCHEMBL10603795 | 0.81 | MTNR1A (0.59) | MTNR1AMTNR1BHTTHPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0393574-B1 | Hexitol derivatives | KYOWA HAKKO KOGYO KK (JP) | 1996-01-31 | — | — | EP | disclosed |
| US-5053408-A | Cardiovascular disorders | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1991-10-01 | — | — | US | disclosed |
| EP-0393574-A2 | Hexitol derivatives | KYOWA HAKKO KOGYO CO., LTD. (JP) | 1990-10-24 | — | — | EP | disclosed |