Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 3/20 | 0.51 |
| ▸ | SCN4A | P35499 | 4/20 | 0.48 |
| ▸ | GABRP | O00591 | 1/20 | 0.43 |
| ▸ | GABRD | O14764 | 1/20 | 0.43 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.43 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.43 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.43 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.43 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.43 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.43 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.43 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.43 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.43 |
| ▸ | GABRE | P78334 | 1/20 | 0.43 |
| ▸ | GABRA6 | Q16445 | 1/20 | 0.43 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.43 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.43 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.43 |
| ▸ | RPA1 | P27694 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22341331 | 0.83 | SCN4A (0.55) | SCN9ASCN4AGABRPGABRDGABRA1 | |
| SCHEMBL21590334 | 0.82 | SCN4A (0.48) | SCN9ASCN4ASMN1; SMN2KDM4ENPC1 | |
| SCHEMBL22341260 | 0.82 | SCN4A (0.61) | SCN9ASCN4ASMN1; SMN2RPA1MAPT | |
| SCHEMBL16974003 | 0.82 | SMN1; SMN2 (0.50) | SCN9ASCN4ASMN1; SMN2MAPTALPL | |
| SCHEMBL18128031 | 0.82 | KEAP1 (0.55) | SCN9ASCN4ASMN1; SMN2RPA1MAPT | |
| SCHEMBL7055588 | 0.78 | SCN4A (0.55) | SCN4AGABRPGABRDGABRA1GABRB1 | |
| SCHEMBL12988415 | 0.78 | SCN9A (0.48) | SCN9ASCN4AGABRPGABRDGABRA1 | |
| SCHEMBL25411454 | 0.77 | SCN4A (0.50) | SCN9ASCN4ASMN1; SMN2MAPTCA12 | |
| SCHEMBL18127956 | 0.77 | SCN4A (0.65) | SCN9ASCN4AGABRA1GABRB2SMN1; SMN2 | |
| SCHEMBL4760337 | 0.77 | POLB (0.47) | GABRA5MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2903979-B1 | NOVEL COMPOUNDS, THEIR PREPARATION AND THEIR USES | INHIBIKASE THERAPEUTICS INC (US) | 2020-08-19 | — | — | EP | claimed |
| EP-0731796-A1 | 1,3,5-TRISUBSTITUTED PYRAZOLE COMPOUNDS FOR TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1996-09-18 | — | — | EP | disclosed |
| WO-1995015318-A1 | 1,3,5-TRISUBSTITUTED PYRAZOLE COMPOUNDS FOR TREATMENT OF INFLAMMATION | G.D. SEARLE & CO. (US) | 1995-06-08 | — | — | WO | disclosed |