Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TYMS | P04818 | 7/20 | 0.55 |
| ▸ | DHFR | P00374 | 5/20 | 0.55 |
| ▸ | FOLR1 | P15328 | 7/20 | 0.55 |
| ▸ | SLC19A1 | P41440 | 6/20 | 0.55 |
| ▸ | SLC46A1 | Q96NT5 | 6/20 | 0.55 |
| ▸ | GART | P22102 | 2/20 | 0.53 |
| ▸ | FOLR2 | P14207 | 2/20 | 0.48 |
| ▸ | EHMT2 | Q96KQ7 | 1/20 | 0.48 |
| ▸ | ATIC | P31939 | 1/20 | 0.46 |
| ▸ | SHMT1 | P34896 | 1/20 | 0.46 |
| ▸ | FRK | P42685 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9226749 | 0.97 | FOLR1 (0.52) | TYMSDHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL9219313 | 0.97 | FOLR1 (0.52) | TYMSDHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL9041174 | 0.93 | DHFR (0.55) | TYMSDHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL9039369 | 0.88 | TYMS (0.52) | TYMSDHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL10448069 | 0.87 | FOLR1 (0.51) | TYMSDHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL9224838 | 0.85 | TYMS (0.49) | TYMSDHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL9228897 | 0.85 | TYMS (0.49) | TYMSDHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL9439839 | 0.85 | FOLR1 (0.74) | TYMSDHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL9227692 | 0.84 | TYMS (0.50) | TYMSDHFRFOLR1SLC19A1SLC46A1 | |
| SCHEMBL9691410 | 0.84 | TYMS (0.50) | TYMSDHFRFOLR1SLC19A1SLC46A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0400562-B1 | Pyrrolopyrimidines, their production and use as tumoricidal agents | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1996-08-21 | — | — | EP | disclosed |