Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.42 |
| ▸ | WNT3A | P56704 | 1/20 | 0.39 |
| ▸ | CYP4F2 | P78329 | 3/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10067601 | 1.00 | GPR119 (0.42) | GPR119WNT3ACYP4F2CYP4A11KDM4E | |
| SCHEMBL904048 | 0.91 | GPR119 (0.46) | GPR119KDM4ENPC1RAB9ACCNT1 | |
| SCHEMBL903923 | 0.90 | GPR119 (0.51) | GPR119WNT3ACYP4F2CYP4A11CCNT1 | |
| SCHEMBL1092945 | 0.87 | GPR119 (0.53) | GPR119WNT3ACYP4F2CYP4A11KDM4E | |
| SCHEMBL903996 | 0.83 | GPR119 (0.40) | GPR119WNT3ACYP4F2CYP4A11KDM4E | |
| SCHEMBL903925 | 0.81 | GPR119 (0.53) | GPR119WNT3ACYP4F2CYP4A11 | |
| SCHEMBL904057 | 0.81 | GPR119 (0.46) | GPR119CCNT1CDK9ENPP2 | |
| SCHEMBL904166 | 0.81 | GPR119 (0.45) | GPR119CCNT1CDK9ENPP2 | |
| SCHEMBL903993 | 0.81 | GPR119 (0.40) | GPR119WNT3ACYP4F2CYP4A11CCNT1 | |
| SCHEMBL904056 | 0.81 | GPR119 (0.40) | GPR119WNT3ACYP4F2CYP4A11CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041158-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-04-05 | — | — | WO | disclosed |