Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 3/20 | 0.50 |
| ▸ | ACLY | P53396 | 3/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TPMT | P51580 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.39 |
| ▸ | PLAU | P00749 | 1/20 | 0.39 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.38 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
| ▸ | CDC25B | P30305 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL184545 | 0.83 | TTR (0.64) | TTRACLYTSHRTPMTTDP1 | |
| SCHEMBL30657973 | 0.83 | TTR (0.64) | TTRACLYTSHRTPMTTDP1 | |
| SCHEMBL9038640 | 0.83 | TTR (0.48) | TTRACLYTSHRTPMTTDP1 | |
| SCHEMBL9042101 | 0.83 | CA1 (0.56) | TTRACLYTSHRTPMTTDP1 | |
| SCHEMBL9436611 | 0.83 | TTR (0.48) | TTRACLYTSHRTPMTTDP1 | |
| SCHEMBL10934779 | 0.81 | TTR (0.47) | TTRACLYTSHRTPMTTDP1 | |
| SCHEMBL9436604 | 0.81 | TTR (0.47) | TTRACLYTSHRTPMTTDP1 | |
| SCHEMBL29070103 | 0.81 | TTR (0.47) | TTRACLYTSHRTPMTTDP1 | |
| SCHEMBL7263572 | 0.79 | TTR (0.68) | TTRTSHRTPMTTDP1SMN1; SMN2 | |
| SCHEMBL396004 | 0.77 | TDP1 (0.61) | TSHRTDP1KMT2ASMN1; SMN2SRD5A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0556674-B1 | 3,5-substituted benzoylguanidines with antiarrhythmic activity and cell proliferation inhibiting activity | HOECHST AG (DE) | 1996-06-19 | — | — | EP | disclosed |
| US-5373024-A | 3,5-Substituted benzoylguanidines, process for their preparation, their use as a medicament of diagnostic and medicament containing them | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-12-13 | — | — | US | disclosed |
| EP-0556674-A1 | 3,5-substituted benzoylguanidines with antiarrhythmic activity and cell proliferation inhibiting activity | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-08-25 | — | — | EP | disclosed |