SCHEMBL396004

SCHEMBL396004

O=C(O)c1ccc(Cl)c(S(=O)(=O)Cl)c1

nearest known ligand 0.61

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
TDP1 Q9NUW8 3/20 0.61
KMT2A Q03164 5/20 0.59
SMN1; SMN2 Q16637 1/20 0.59
TSHR P16473 1/20 0.59
POLB P06746 4/20 0.55
HSD17B10 Q99714 1/20 0.55
MEN1 O00255 4/20 0.51
L3MBTL1 Q9Y468 3/20 0.51
KDM4E B2RXH2 2/20 0.50
MAPK1 P28482 1/20 0.50
CDC25B P30305 1/20 0.50
HTT P42858 1/20 0.49
MAPT P10636 2/20 0.49
ALDH1A1 P00352 1/20 0.49
SRD5A2 P31213 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1926208 0.85 TDP1 (0.45) TDP1KMT2ASMN1; SMN2TSHRPOLB
SCHEMBL2780755 0.85 TDP1 (0.61) TDP1KMT2ASMN1; SMN2TSHRPOLB
SCHEMBL30315798 0.85 TSHR (0.59) TDP1KMT2ASMN1; SMN2TSHRPOLB
SCHEMBL3158500 0.85 TSHR (0.59) TDP1KMT2ASMN1; SMN2TSHRPOLB
SCHEMBL31670541 0.83 CA1 (0.63) TDP1KMT2ASMN1; SMN2TSHRPOLB
SCHEMBL329732 0.83 CA1 (0.63) TDP1KMT2ASMN1; SMN2TSHRPOLB
SCHEMBL2198935 0.83 SMN1; SMN2 (0.46) TDP1KMT2ASMN1; SMN2TSHRPOLB
SCHEMBL1495405 0.83 KMT2A (0.62) TDP1KMT2ASMN1; SMN2TSHRPOLB
Hydrochloric Acid SCHEMBL7951765 0.81 CA1 (0.61) TDP1KMT2ASMN1; SMN2TSHRPOLB
SCHEMBL27878675 0.81 CA1 (0.61) TDP1KMT2ASMN1; SMN2TSHRPOLB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 218 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115724641-B Mildew-proof antibacterial autoclaved aerated block and preparation method thereof 广州市贤达建材有限公司 2024-02-23 CN claimed
CN-115677544-A Preparation method of bumetanide 中科苏州药物研究院 2023-02-03 CN claimed
CN-104672114-A A preparing method of 2,4-dichloro-5-sulfamoylbenzoic acid MEN XIUXIN 2015-06-03 CN claimed
JP-3056440-A None JP disclosed
US-12496282-B2 Hepatitis B antiviral agents ENANTA PHARMACEUTICALS, INC. (US) 2025-12-16 US disclosed
WO-2025215115-A1 COMPOUNDS FOR USE THE TREATMENT OF CANCER, NEURODEGENERATIVE DISEASES, PSYCHIATRIC DISORDERS, INFLAMMATION, EPILEPSY AND SEIZURES B&A ONCOMEDICAL (FR) 2025-10-16 WO disclosed
EP-4601744-A1 NEW COMPOUNDS, PROCESSES FOR PREPARING THE SAME AND THEIR USE AS DRUGS B&A Oncomedical (FR) 2025-08-20 EP disclosed
US-20240366538-A1 Hepatitis B Antiviral Agents ENANTA PHARM INC (US) 2024-11-07 US disclosed
US-12054493-B2 Hepatitis B antiviral agents ENANTA PHARMACEUTICALS, INC. (US) 2024-08-06 US disclosed
US-12011425-B2 Hepatitis B antiviral agents ENANTA PHARMACEUTICALS, INC. (US) 2024-06-18 US disclosed
EP-2984072-B1 SYNTHETIC ANALOGUES OF XANTHOHUMOL UNIV PISA (IT) 2024-05-29 EP disclosed
EP-0127124-A2 Compounds for treating hypertension USV PHARMACEUTICAL CORPORATION (US) 1984-12-05 EP disclosed
US-4377521-A ANTILIPEMIC PFIZER INC. (US) 1983-03-22 US disclosed
EP-0068407-A1 Aminosulfonylbenzoic acid derivatives HODOGAYA CHEMICAL CO., LTD. (JP) 1983-01-05 EP disclosed
US-4138399-A Sulfamylbenzoic acid PFIZER INC. (US) 1979-02-06 US disclosed
US-4125614-A DIURETIC HOECHST AKTIENGESELLSCHAFT (DE) 1978-11-14 US disclosed
US-4124590-A CARDIOVASCULAR DISORDERS, ANTILIPEMIC AGENTS PFIZER INC. (US) 1978-11-07 US disclosed
US-4061761-A Thiazolidine derivatives HOECHST AKTIENGESELLSCHAFT (DT) 1977-12-06 US disclosed
US-3992441-A ANTILIPEMIC PFIZER INC. (US) 1976-11-16 US disclosed
US-3953476-A DIURETICS MERCK & CO., INC. (US) 1976-04-27 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12054493-B2 Hepatitis B antiviral agents HAVCR2, PYGL, SLC10A1 TDP1 3722/4885KMT2A 3350/4885SMN1; SMN2 4765/4885
US-12011425-B2 Hepatitis B antiviral agents HAVCR2, PYGL, SLC10A1 TDP1 3722/4885KMT2A 3350/4885SMN1; SMN2 4765/4885
US-20240366538-A1 Hepatitis B Antiviral Agents HAVCR2, PYGL, SLC10A1 TDP1 3722/4885KMT2A 3350/4885SMN1; SMN2 4765/4885
US-12496282-B2 Hepatitis B antiviral agents HAVCR2, PYGL, SLC10A1 TDP1 3722/4885KMT2A 3350/4885SMN1; SMN2 4765/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.