Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE8B | O95263 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 12/20 | 0.40 |
| ▸ | ACACB | O00763 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | OGA | O60502 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10067572 | 0.91 | ACACB (0.44) | PDE8BGPR119ACACBKDM4ENPC1 | |
| SCHEMBL10067707 | 0.91 | ACACB (0.44) | PDE8BGPR119ACACBKDM4ENPC1 | |
| SCHEMBL14247009 | 0.85 | GPR119 (0.46) | PDE8BGPR119KDM4ENPC1RAB9A | |
| SCHEMBL12506042 | 0.78 | AOC3 (0.49) | PDE8BGPR119ACACBOGA | |
| SCHEMBL15312801 | 0.78 | AOC3 (0.49) | PDE8BGPR119ACACBOGA | |
| SCHEMBL12503204 | 0.78 | HRH4 (0.47) | PDE8BGPR119KCNH2OGA | |
| SCHEMBL15189865 | 0.78 | GPR119 (0.44) | PDE8BGPR119KDM4ENPC1RAB9A | |
| SCHEMBL10068057 | 0.77 | NPC1 (0.40) | PDE8BGPR119ACACBKDM4ENPC1 | |
| SCHEMBL14315929 | 0.77 | HRH3 (0.41) | PDE8BGPR119KDM4ENPC1RAB9A | |
| SCHEMBL12239174 | 0.76 | TSHR (0.50) | PDE8BGPR119KDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041158-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-04-05 | — | — | WO | disclosed |