Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPL | P06858 | 13/20 | 0.47 |
| ▸ | LIPG | Q9Y5X9 | 13/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 3/20 | 0.36 |
| ▸ | CA2 | P00918 | 3/20 | 0.36 |
| ▸ | CA9 | Q16790 | 3/20 | 0.36 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA3 | P07451 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.36 |
| ▸ | F11 | P03951 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | TDO2 | P48775 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL239104 | 0.79 | LPL (0.56) | LPLLIPGROCK1CA1CA2 | |
| SCHEMBL16071125 | 0.77 | ESR2 (0.39) | LPLLIPGCA1CA2CA9 | |
| SCHEMBL59080 | 0.76 | LPL (0.53) | LPLLIPGROCK1CA1CA2 | |
| SCHEMBL2640296 | 0.76 | LPL (0.53) | LPLLIPGROCK1CA1CA2 | |
| SCHEMBL17491867 | 0.76 | LPL (0.53) | LPLLIPGROCK1CA1CA2 | |
| SCHEMBL19647680 | 0.75 | ROCK1 (0.40) | LPLLIPGROCK1CA1CA2 | |
| SCHEMBL12496719 | 0.75 | LPL (0.51) | LPLLIPGROCK1CA1CA2 | |
| SCHEMBL2130844 | 0.75 | LPL (0.51) | LPLLIPGROCK1CA1CA2 | |
| SCHEMBL581686 | 0.75 | LPL (0.51) | LPLLIPGROCK1CA1CA2 | |
| SCHEMBL31342073 | 0.75 | LPL (0.51) | LPLLIPGROCK1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012041158-A1 | TRICYCLIC COMPOUND, PREPARATION METHOD AND PHARMACEUTICAL USE THEREOF | 上海恒瑞医药有限公司 (CN) | 2012-04-05 | — | — | WO | disclosed |