Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 5/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.43 |
| ▸ | IDH2 | P48735 | 1/20 | 0.41 |
| ▸ | MAP3K12 | Q12852 | 7/20 | 0.40 |
| ▸ | KIF11 | P52732 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CLK1 | P49759 | 1/20 | 0.38 |
| ▸ | PHGDH | O43175 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13737025 | 0.85 | SYK (0.46) | SYKIDH2MAP3K12KIF11ALDH1A1 | |
| SCHEMBL16820221 | 0.83 | SYK (0.54) | SYKIDH2MAP3K12 | |
| SCHEMBL1704102 | 0.81 | KMT2A (0.50) | SYKALDH1A1 | |
| SCHEMBL13827142 | 0.80 | SYK (0.49) | SYKIDH2MAP3K12ALDH1A1GAA | |
| SCHEMBL13827138 | 0.76 | IDH2 (0.46) | SYKIDH2MAP3K12 | |
| SCHEMBL902723 | 0.76 | POLB (0.44) | ALDH1A1 | |
| SCHEMBL902494 | 0.75 | IDH2 (0.56) | SYKIDH2MAP3K12 | |
| SCHEMBL13827438 | 0.74 | MAP3K12 (0.50) | SYKMAP3K12 | |
| SCHEMBL16205244 | 0.74 | SYK (0.46) | SYKIDH2MAP3K12KIF11ALDH1A1 | |
| SCHEMBL16205251 | 0.72 | SYK (0.48) | SYKIDH2MAP3K12KIF11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |